Evolution of H5N1 avian influenza viruses in Asia

Jean Thierry Aubin; Saliha Azebi; Amanda Balish; Jill Banks; Niranjan Bhat; Rick A. Bright; Ian Brown; Philippe Buchy; Ana Maria Burguiere; Hua Ian Chen; Peter Cheng; Nancy J. Cox; Alice Crosier; Aaron Curns; Frédèrique Cuvelier; Guohua Deng; Julia Desheva; Stéphanie Desvaux; Nguyen Hong Diep; Ruben O. Donis; Alan Douglas; Scott F. Dowell; Nguyen Tien Dung; Lindsay Edwards; Keiji Fukuda; Rebecca Garten; Elena Govorkova; Victoria Gregory; Alan Hampson; Nguyen Thi Hong Hanh; Scott Harper; Alan Hay; Erich Hoffmann; Diane Hulse; Masaki Imai; Shigeyuki Itamura; Samadhan Jadhao; Patricia Jeannin; Chun Kang; Jackie Katz; Jae Hong Kim; Alexander Klimov; Yong Kuk Kwon; Chang Won Lee; Phuong Song Lien; Yanbing Li; Wilina Lim; Yi Pu Lin; Stephen Lindstom; La Morris Loftin; Jan Mabry; Le Quynh Mai; Taronna Maines; Jean Claude Manuguerra; Masaji Mase; Yumi Matsuoka; Margaret McCarron; Marie Jo Medina; Doan Nguyen; Ai Ninomiya; Masatsugu Obuchi; Takato Odagiri; Malik Peiris; Michael L. Perdue; Jean Marc Reynes; James Robertson; Claudine Rousseaux; Takehiko Saito; Somchai Sangkitporn; Michael Shaw; James M. Simmerman; M. Slomka; Catherine Smith; San Sorn; Erica Spackman; Klaus Stöhr; David L. Suarez; Haan Woo Sung; David E. Swayne; Maryse Tardy-Panit; Masato Tashiro; Pranee Thawatsupha; Terrence Tumpey; Timothy Uyeki; Phan Van Tu; Sylvie Van Der Werf; Sirenda Vong; Richard Webby; Robert Webster; John Wood; Xiyan Xu; Guan Yi; Wenging Zhang

doi:10.3201/eid1110.050644

Evolution of H5N1 avian influenza viruses in Asia

Jean Thierry Aubin, Saliha Azebi, Amanda Balish, Jill Banks, Niranjan Bhat, Rick A. Bright, Ian Brown, Philippe Buchy, Ana Maria Burguiere, Hua Ian Chen, Peter Cheng, Nancy J. Cox, Alice Crosier, Aaron Curns, Frédèrique Cuvelier, Guohua Deng, Julia Desheva, Stéphanie Desvaux, Nguyen Hong Diep, Ruben O. DonisAlan Douglas, Scott F. Dowell, Nguyen Tien Dung, Lindsay Edwards, Keiji Fukuda, Rebecca Garten, Elena Govorkova, Victoria Gregory, Alan Hampson, Nguyen Thi Hong Hanh, Scott Harper, Alan Hay, Erich Hoffmann, Diane Hulse, Masaki Imai, Shigeyuki Itamura, Samadhan Jadhao, Patricia Jeannin, Chun Kang, Jackie Katz, Jae Hong Kim, Alexander Klimov, Yong Kuk Kwon, Chang Won Lee, Phuong Song Lien, Yanbing Li, Wilina Lim, Yi Pu Lin, Stephen Lindstom, La Morris Loftin, Jan Mabry, Le Quynh Mai, Taronna Maines, Jean Claude Manuguerra, Masaji Mase, Yumi Matsuoka, Margaret McCarron, Marie Jo Medina, Doan Nguyen, Ai Ninomiya, Masatsugu Obuchi, Takato Odagiri, Malik Peiris, Michael L. Perdue, Jean Marc Reynes, James Robertson, Claudine Rousseaux, Takehiko Saito, Somchai Sangkitporn, Michael Shaw, James M. Simmerman, M. Slomka, Catherine Smith, San Sorn, Erica Spackman, Klaus Stöhr, David L. Suarez, Haan Woo Sung, David E. Swayne, Maryse Tardy-Panit, Masato Tashiro, Pranee Thawatsupha, Terrence Tumpey, Timothy Uyeki, Phan Van Tu, Sylvie Van Der Werf, Sirenda Vong, Richard Webby, Robert Webster, John Wood, Xiyan Xu, Guan Yi, Wenging Zhang

Research output: Contribution to journal › Article › peer-review

342 Scopus citations

Abstract

An outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused ≥52 human deaths in Vietnam, Thailand, and Cambodia from January 2004 to April 2005. Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. All human H5N1 isolates tested belonged to a single clade and were resistant to the adamantane drugs but sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were antigenically homogeneous and distinct from avian viruses circulating before the end of 2003. Some 2005 isolates showed evidence of antigenic drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans.

Original language	English (US)
Pages (from-to)	1515-1521
Number of pages	7
Journal	Emerging infectious diseases
Volume	11
Issue number	10
DOIs	https://doi.org/10.3201/eid1110.050644
State	Published - Oct 2005
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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10.3201/eid1110.050644

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Aubin, J. T., Azebi, S., Balish, A., Banks, J., Bhat, N., Bright, R. A., Brown, I., Buchy, P., Burguiere, A. M., Chen, H. I., Cheng, P., Cox, N. J., Crosier, A., Curns, A., Cuvelier, F., Deng, G., Desheva, J., Desvaux, S., Diep, N. H., ... Zhang, W. (2005). Evolution of H5N1 avian influenza viruses in Asia. Emerging infectious diseases, 11(10), 1515-1521. https://doi.org/10.3201/eid1110.050644

Aubin, JT, Azebi, S, Balish, A, Banks, J, Bhat, N, Bright, RA, Brown, I, Buchy, P, Burguiere, AM, Chen, HI, Cheng, P, Cox, NJ, Crosier, A, Curns, A, Cuvelier, F, Deng, G, Desheva, J, Desvaux, S, Diep, NH, Donis, RO, Douglas, A, Dowell, SF, Dung, NT, Edwards, L, Fukuda, K, Garten, R, Govorkova, E, Gregory, V, Hampson, A, Hanh, NTH, Harper, S, Hay, A, Hoffmann, E, Hulse, D, Imai, M, Itamura, S, Jadhao, S, Jeannin, P, Kang, C, Katz, J, Kim, JH, Klimov, A, Kwon, YK, Lee, CW, Lien, PS, Li, Y, Lim, W, Lin, YP, Lindstom, S, Loftin, LM, Mabry, J, Mai, LQ, Maines, T, Manuguerra, JC, Mase, M, Matsuoka, Y, McCarron, M, Medina, MJ, Nguyen, D, Ninomiya, A, Obuchi, M, Odagiri, T, Peiris, M, Perdue, ML, Reynes, JM, Robertson, J, Rousseaux, C, Saito, T, Sangkitporn, S, Shaw, M, Simmerman, JM, Slomka, M, Smith, C, Sorn, S, Spackman, E, Stöhr, K, Suarez, DL, Sung, HW, Swayne, DE, Tardy-Panit, M, Tashiro, M, Thawatsupha, P, Tumpey, T, Uyeki, T, Van Tu, P, Van Der Werf, S, Vong, S, Webby, R, Webster, R, Wood, J, Xu, X, Yi, G & Zhang, W 2005, 'Evolution of H5N1 avian influenza viruses in Asia', Emerging infectious diseases, vol. 11, no. 10, pp. 1515-1521. https://doi.org/10.3201/eid1110.050644

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title = "Evolution of H5N1 avian influenza viruses in Asia",

abstract = "An outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused ≥52 human deaths in Vietnam, Thailand, and Cambodia from January 2004 to April 2005. Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. All human H5N1 isolates tested belonged to a single clade and were resistant to the adamantane drugs but sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were antigenically homogeneous and distinct from avian viruses circulating before the end of 2003. Some 2005 isolates showed evidence of antigenic drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans.",

author = "Aubin, {Jean Thierry} and Saliha Azebi and Amanda Balish and Jill Banks and Niranjan Bhat and Bright, {Rick A.} and Ian Brown and Philippe Buchy and Burguiere, {Ana Maria} and Chen, {Hua Ian} and Peter Cheng and Cox, {Nancy J.} and Alice Crosier and Aaron Curns and Fr{\'e}d{\`e}rique Cuvelier and Guohua Deng and Julia Desheva and St{\'e}phanie Desvaux and Diep, {Nguyen Hong} and Donis, {Ruben O.} and Alan Douglas and Dowell, {Scott F.} and Dung, {Nguyen Tien} and Lindsay Edwards and Keiji Fukuda and Rebecca Garten and Elena Govorkova and Victoria Gregory and Alan Hampson and Hanh, {Nguyen Thi Hong} and Scott Harper and Alan Hay and Erich Hoffmann and Diane Hulse and Masaki Imai and Shigeyuki Itamura and Samadhan Jadhao and Patricia Jeannin and Chun Kang and Jackie Katz and Kim, {Jae Hong} and Alexander Klimov and Kwon, {Yong Kuk} and Lee, {Chang Won} and Lien, {Phuong Song} and Yanbing Li and Wilina Lim and Lin, {Yi Pu} and Stephen Lindstom and Loftin, {La Morris} and Jan Mabry and Mai, {Le Quynh} and Taronna Maines and Manuguerra, {Jean Claude} and Masaji Mase and Yumi Matsuoka and Margaret McCarron and Medina, {Marie Jo} and Doan Nguyen and Ai Ninomiya and Masatsugu Obuchi and Takato Odagiri and Malik Peiris and Perdue, {Michael L.} and Reynes, {Jean Marc} and James Robertson and Claudine Rousseaux and Takehiko Saito and Somchai Sangkitporn and Michael Shaw and Simmerman, {James M.} and M. Slomka and Catherine Smith and San Sorn and Erica Spackman and Klaus St{\"o}hr and Suarez, {David L.} and Sung, {Haan Woo} and Swayne, {David E.} and Maryse Tardy-Panit and Masato Tashiro and Pranee Thawatsupha and Terrence Tumpey and Timothy Uyeki and {Van Tu}, Phan and {Van Der Werf}, Sylvie and Sirenda Vong and Richard Webby and Robert Webster and John Wood and Xiyan Xu and Guan Yi and Wenging Zhang",

year = "2005",

month = oct,

doi = "10.3201/eid1110.050644",

language = "English (US)",

volume = "11",

pages = "1515--1521",

journal = "Emerging infectious diseases",

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T1 - Evolution of H5N1 avian influenza viruses in Asia

AU - Aubin, Jean Thierry

AU - Azebi, Saliha

AU - Balish, Amanda

AU - Banks, Jill

AU - Bhat, Niranjan

AU - Bright, Rick A.

AU - Brown, Ian

AU - Buchy, Philippe

AU - Burguiere, Ana Maria

AU - Chen, Hua Ian

AU - Cheng, Peter

AU - Cox, Nancy J.

AU - Crosier, Alice

AU - Curns, Aaron

AU - Cuvelier, Frédèrique

AU - Deng, Guohua

AU - Desheva, Julia

AU - Desvaux, Stéphanie

AU - Diep, Nguyen Hong

AU - Donis, Ruben O.

AU - Douglas, Alan

AU - Dowell, Scott F.

AU - Dung, Nguyen Tien

AU - Edwards, Lindsay

AU - Fukuda, Keiji

AU - Garten, Rebecca

AU - Govorkova, Elena

AU - Gregory, Victoria

AU - Hampson, Alan

AU - Hanh, Nguyen Thi Hong

AU - Harper, Scott

AU - Hay, Alan

AU - Hoffmann, Erich

AU - Hulse, Diane

AU - Imai, Masaki

AU - Itamura, Shigeyuki

AU - Jadhao, Samadhan

AU - Jeannin, Patricia

AU - Kang, Chun

AU - Katz, Jackie

AU - Kim, Jae Hong

AU - Klimov, Alexander

AU - Kwon, Yong Kuk

AU - Lee, Chang Won

AU - Lien, Phuong Song

AU - Li, Yanbing

AU - Lim, Wilina

AU - Lin, Yi Pu

AU - Lindstom, Stephen

AU - Loftin, La Morris

AU - Mabry, Jan

AU - Mai, Le Quynh

AU - Maines, Taronna

AU - Manuguerra, Jean Claude

AU - Mase, Masaji

AU - Matsuoka, Yumi

AU - McCarron, Margaret

AU - Medina, Marie Jo

AU - Nguyen, Doan

AU - Ninomiya, Ai

AU - Obuchi, Masatsugu

AU - Odagiri, Takato

AU - Peiris, Malik

AU - Perdue, Michael L.

AU - Reynes, Jean Marc

AU - Robertson, James

AU - Rousseaux, Claudine

AU - Saito, Takehiko

AU - Sangkitporn, Somchai

AU - Shaw, Michael

AU - Simmerman, James M.

AU - Slomka, M.

AU - Smith, Catherine

AU - Sorn, San

AU - Spackman, Erica

AU - Stöhr, Klaus

AU - Suarez, David L.

AU - Sung, Haan Woo

AU - Swayne, David E.

AU - Tardy-Panit, Maryse

AU - Tashiro, Masato

AU - Thawatsupha, Pranee

AU - Tumpey, Terrence

AU - Uyeki, Timothy

AU - Van Tu, Phan

AU - Van Der Werf, Sylvie

AU - Vong, Sirenda

AU - Webby, Richard

AU - Webster, Robert

AU - Wood, John

AU - Xu, Xiyan

AU - Yi, Guan

AU - Zhang, Wenging

PY - 2005/10

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N2 - An outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused ≥52 human deaths in Vietnam, Thailand, and Cambodia from January 2004 to April 2005. Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. All human H5N1 isolates tested belonged to a single clade and were resistant to the adamantane drugs but sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were antigenically homogeneous and distinct from avian viruses circulating before the end of 2003. Some 2005 isolates showed evidence of antigenic drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans.

AB - An outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused ≥52 human deaths in Vietnam, Thailand, and Cambodia from January 2004 to April 2005. Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. All human H5N1 isolates tested belonged to a single clade and were resistant to the adamantane drugs but sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were antigenically homogeneous and distinct from avian viruses circulating before the end of 2003. Some 2005 isolates showed evidence of antigenic drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans.

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JO - Emerging infectious diseases

JF - Emerging infectious diseases

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Evolution of H5N1 avian influenza viruses in Asia

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