Evolution of chronic nitric oxide inhibition hypertension relationship to renal function

Changbin Qiu, Dianne Muchant, William H. Beierwaltes, Lorraine C Racusen, Chris Baylis

Research output: Contribution to journalArticle

Abstract

We conducted longitudinal measurements of blood pressure and renal function in the conscious, chronically catheterized rat before and during acute nitric oxide synthase inhibition (N-nitro-L-arginine methylester [L- NAME], 37 μmol/kg IV) and then chronic administration of oral L-NAME (≃37 μmol/kg per 24 hours). These studies specifically investigate the impact on plasma and renal renin as well as volume status during the evolution of this hypertension in rats not subjected to acute experimental stress. Blood pressure progressively increased with chronic administration of L-NAME and reached values greatly above those seen with acute administration of L-NAME. There were parallel increases in renal vascular resistance and development of proteinuria, and glomerular filtration rate began to decline at day 21, coincident with the appearance of renal damage. Twenty-four-hour urinary nitrite and nitrate excretion remained depressed, reflecting reduced nitric oxide synthesis. The plasma renin activity was variable and only increased transiently at 21 days, thus the angiotensin II dependence of this hypertension is not caused by stimulated plasma renin activity. Despite severe hypertension, sodium intake and excretion were unchanged over the 21 days of L-NAME administration. Plasma volume was significantly reduced at days 2 and 12 of L-NAME administration; thus the prolonged plasma volume contraction must result from the acute natriuretic response to the initial acute L-NAME administration.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalHypertension
Volume31
Issue number1 I
StatePublished - Jan 1998

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NG-Nitroarginine Methyl Ester
Nitric Oxide
Hypertension
Kidney
Renin
Plasma Volume
Blood Pressure
Nitrites
Glomerular Filtration Rate
Proteinuria
Nitric Oxide Synthase
Angiotensin II
Vascular Resistance
Nitrates
Oral Administration
Arginine
Sodium

Keywords

  • N-nitro-L-arginine methylester
  • Natriuresis
  • Nitric oxide
  • Plasma volume
  • Renal vascular resistance

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Qiu, C., Muchant, D., Beierwaltes, W. H., Racusen, L. C., & Baylis, C. (1998). Evolution of chronic nitric oxide inhibition hypertension relationship to renal function. Hypertension, 31(1 I), 21-26.

Evolution of chronic nitric oxide inhibition hypertension relationship to renal function. / Qiu, Changbin; Muchant, Dianne; Beierwaltes, William H.; Racusen, Lorraine C; Baylis, Chris.

In: Hypertension, Vol. 31, No. 1 I, 01.1998, p. 21-26.

Research output: Contribution to journalArticle

Qiu, C, Muchant, D, Beierwaltes, WH, Racusen, LC & Baylis, C 1998, 'Evolution of chronic nitric oxide inhibition hypertension relationship to renal function', Hypertension, vol. 31, no. 1 I, pp. 21-26.
Qiu C, Muchant D, Beierwaltes WH, Racusen LC, Baylis C. Evolution of chronic nitric oxide inhibition hypertension relationship to renal function. Hypertension. 1998 Jan;31(1 I):21-26.
Qiu, Changbin ; Muchant, Dianne ; Beierwaltes, William H. ; Racusen, Lorraine C ; Baylis, Chris. / Evolution of chronic nitric oxide inhibition hypertension relationship to renal function. In: Hypertension. 1998 ; Vol. 31, No. 1 I. pp. 21-26.
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