Evolution of cerebral ischemia assessed by amide proton transfer-weighted MRI

Guodong Song, Chunmei Li, Xiaojie Luo, Xuna Zhao, Shuai Zhang, Yi Zhang, Shanshan Jiang, Xianlong Wang, Yuhui Chen, Haibo Chen, Tao Gong, Jinyuan Zhou, Min Chen

Research output: Contribution to journalArticle

Abstract

Amide proton transfer-weighted (APTW) magnetic resonance imaging (MRI) has recently become a potentially important tool for evaluating acidosis in ischemic stroke. The purpose of this study was to evaluate the dynamic pH-related changes in the lesions in patients with ischemia. Thirty-nine patients with ischemic stroke (symptom onset to imaging time ranging 2 h-7 days) were examined with a 3.0-T MRI system. Patients were divided into four groups: at the hyperacute stage (onset time ≤ 6 h), at the acute stage (6 h < onset time ≤ 48 h), at the early subacute stage (48 h < onset time ≤ 96 h), and at the late subacute stage (96 h < onset time ≤ 168 h). The APTW signal intensities were quantitatively measured in multiple ischemic regions for each patient. Compared with the contralateral normal white matter, APTW signals were significantly lower in ischemic tissue for all four stages (P < 0.05). The APTW signal intensities (APTWave and APTWmin) increased consistently with onset time (R2 = 0.11, P = 0.040; R2 = 0.13, P = 0.022, respectively). APTWmax-min showed a continued reduction with onset time (R2 = 0.44, P < 0.001). Our results suggest that persistent tissue acidification could occur after ischemia, and as the time from stroke onset increases, the acidotic environment would alleviate. APTW signal intensities could reflect pH-weighted properties in ischemic tissue at different stages and time points.

Original languageEnglish (US)
Article number67
JournalFrontiers in Neurology
Volume8
Issue numberMAR
DOIs
StatePublished - Mar 2 2017

Fingerprint

Brain Ischemia
Amides
Protons
Magnetic Resonance Imaging
Stroke
Ischemia
Acidosis

Keywords

  • APT imaging
  • Chemical exchange saturation transfer imaging
  • Magnetization transfer
  • PH
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Song, G., Li, C., Luo, X., Zhao, X., Zhang, S., Zhang, Y., ... Chen, M. (2017). Evolution of cerebral ischemia assessed by amide proton transfer-weighted MRI. Frontiers in Neurology, 8(MAR), [67]. https://doi.org/10.3389/fneur.2017.00067

Evolution of cerebral ischemia assessed by amide proton transfer-weighted MRI. / Song, Guodong; Li, Chunmei; Luo, Xiaojie; Zhao, Xuna; Zhang, Shuai; Zhang, Yi; Jiang, Shanshan; Wang, Xianlong; Chen, Yuhui; Chen, Haibo; Gong, Tao; Zhou, Jinyuan; Chen, Min.

In: Frontiers in Neurology, Vol. 8, No. MAR, 67, 02.03.2017.

Research output: Contribution to journalArticle

Song, G, Li, C, Luo, X, Zhao, X, Zhang, S, Zhang, Y, Jiang, S, Wang, X, Chen, Y, Chen, H, Gong, T, Zhou, J & Chen, M 2017, 'Evolution of cerebral ischemia assessed by amide proton transfer-weighted MRI', Frontiers in Neurology, vol. 8, no. MAR, 67. https://doi.org/10.3389/fneur.2017.00067
Song, Guodong ; Li, Chunmei ; Luo, Xiaojie ; Zhao, Xuna ; Zhang, Shuai ; Zhang, Yi ; Jiang, Shanshan ; Wang, Xianlong ; Chen, Yuhui ; Chen, Haibo ; Gong, Tao ; Zhou, Jinyuan ; Chen, Min. / Evolution of cerebral ischemia assessed by amide proton transfer-weighted MRI. In: Frontiers in Neurology. 2017 ; Vol. 8, No. MAR.
@article{ce4f41d45bc04fcf842a819940774682,
title = "Evolution of cerebral ischemia assessed by amide proton transfer-weighted MRI",
abstract = "Amide proton transfer-weighted (APTW) magnetic resonance imaging (MRI) has recently become a potentially important tool for evaluating acidosis in ischemic stroke. The purpose of this study was to evaluate the dynamic pH-related changes in the lesions in patients with ischemia. Thirty-nine patients with ischemic stroke (symptom onset to imaging time ranging 2 h-7 days) were examined with a 3.0-T MRI system. Patients were divided into four groups: at the hyperacute stage (onset time ≤ 6 h), at the acute stage (6 h < onset time ≤ 48 h), at the early subacute stage (48 h < onset time ≤ 96 h), and at the late subacute stage (96 h < onset time ≤ 168 h). The APTW signal intensities were quantitatively measured in multiple ischemic regions for each patient. Compared with the contralateral normal white matter, APTW signals were significantly lower in ischemic tissue for all four stages (P < 0.05). The APTW signal intensities (APTWave and APTWmin) increased consistently with onset time (R2 = 0.11, P = 0.040; R2 = 0.13, P = 0.022, respectively). APTWmax-min showed a continued reduction with onset time (R2 = 0.44, P < 0.001). Our results suggest that persistent tissue acidification could occur after ischemia, and as the time from stroke onset increases, the acidotic environment would alleviate. APTW signal intensities could reflect pH-weighted properties in ischemic tissue at different stages and time points.",
keywords = "APT imaging, Chemical exchange saturation transfer imaging, Magnetization transfer, PH, Stroke",
author = "Guodong Song and Chunmei Li and Xiaojie Luo and Xuna Zhao and Shuai Zhang and Yi Zhang and Shanshan Jiang and Xianlong Wang and Yuhui Chen and Haibo Chen and Tao Gong and Jinyuan Zhou and Min Chen",
year = "2017",
month = "3",
day = "2",
doi = "10.3389/fneur.2017.00067",
language = "English (US)",
volume = "8",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",
number = "MAR",

}

TY - JOUR

T1 - Evolution of cerebral ischemia assessed by amide proton transfer-weighted MRI

AU - Song, Guodong

AU - Li, Chunmei

AU - Luo, Xiaojie

AU - Zhao, Xuna

AU - Zhang, Shuai

AU - Zhang, Yi

AU - Jiang, Shanshan

AU - Wang, Xianlong

AU - Chen, Yuhui

AU - Chen, Haibo

AU - Gong, Tao

AU - Zhou, Jinyuan

AU - Chen, Min

PY - 2017/3/2

Y1 - 2017/3/2

N2 - Amide proton transfer-weighted (APTW) magnetic resonance imaging (MRI) has recently become a potentially important tool for evaluating acidosis in ischemic stroke. The purpose of this study was to evaluate the dynamic pH-related changes in the lesions in patients with ischemia. Thirty-nine patients with ischemic stroke (symptom onset to imaging time ranging 2 h-7 days) were examined with a 3.0-T MRI system. Patients were divided into four groups: at the hyperacute stage (onset time ≤ 6 h), at the acute stage (6 h < onset time ≤ 48 h), at the early subacute stage (48 h < onset time ≤ 96 h), and at the late subacute stage (96 h < onset time ≤ 168 h). The APTW signal intensities were quantitatively measured in multiple ischemic regions for each patient. Compared with the contralateral normal white matter, APTW signals were significantly lower in ischemic tissue for all four stages (P < 0.05). The APTW signal intensities (APTWave and APTWmin) increased consistently with onset time (R2 = 0.11, P = 0.040; R2 = 0.13, P = 0.022, respectively). APTWmax-min showed a continued reduction with onset time (R2 = 0.44, P < 0.001). Our results suggest that persistent tissue acidification could occur after ischemia, and as the time from stroke onset increases, the acidotic environment would alleviate. APTW signal intensities could reflect pH-weighted properties in ischemic tissue at different stages and time points.

AB - Amide proton transfer-weighted (APTW) magnetic resonance imaging (MRI) has recently become a potentially important tool for evaluating acidosis in ischemic stroke. The purpose of this study was to evaluate the dynamic pH-related changes in the lesions in patients with ischemia. Thirty-nine patients with ischemic stroke (symptom onset to imaging time ranging 2 h-7 days) were examined with a 3.0-T MRI system. Patients were divided into four groups: at the hyperacute stage (onset time ≤ 6 h), at the acute stage (6 h < onset time ≤ 48 h), at the early subacute stage (48 h < onset time ≤ 96 h), and at the late subacute stage (96 h < onset time ≤ 168 h). The APTW signal intensities were quantitatively measured in multiple ischemic regions for each patient. Compared with the contralateral normal white matter, APTW signals were significantly lower in ischemic tissue for all four stages (P < 0.05). The APTW signal intensities (APTWave and APTWmin) increased consistently with onset time (R2 = 0.11, P = 0.040; R2 = 0.13, P = 0.022, respectively). APTWmax-min showed a continued reduction with onset time (R2 = 0.44, P < 0.001). Our results suggest that persistent tissue acidification could occur after ischemia, and as the time from stroke onset increases, the acidotic environment would alleviate. APTW signal intensities could reflect pH-weighted properties in ischemic tissue at different stages and time points.

KW - APT imaging

KW - Chemical exchange saturation transfer imaging

KW - Magnetization transfer

KW - PH

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=85016149231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016149231&partnerID=8YFLogxK

U2 - 10.3389/fneur.2017.00067

DO - 10.3389/fneur.2017.00067

M3 - Article

VL - 8

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

IS - MAR

M1 - 67

ER -