Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns

César Garriga, Sandra Manzanares-Laya, Patricia García De Olalla, Pilar Gorrindo, Sabela Lens, Ricard Solà, María Martínez-Rebollar, Montserrat Laguno, Jordi Navarro, Xavier Torras, Mercè Gurguí, María Jesús Barberá, Josep Quer, Eva Masdeu, Pere Simón, Miriam Ros, Anna De Andrés, Joan A. Caylà

Research output: Contribution to journalArticle

Abstract

The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases were grouped between 2004–2005, 2006–2011 and 2012–2015, and their incidence rate ratios (IRR) were calculated. In addition, risk factors for acute HCV infection were identified using multinomial logistic regression for complete, available and multiple imputed data. 204 new HCV cases were identified. Two peaks of higher IR of acute HCV infection in 2005 and 2013 were observed. Men and those aged 35–54 had higher IR. IRR for men was 2.9 times greater than in women (95% confidence intervals (CI): 1.8 - 4.7). Factors related to the period 2012–2015 (versus 2006–2011) were: a) sexual risk factor for transmission versus nosocomial (relative-risk ratio (RRR): 13.0; 95% CI: 2.3 - 72.1), b) higher educated versus lower (RRR: 5.4; 95% CI: 1.6 - 18.7), and c) HIV coinfected versus not HIV-infected (RRR: 53.1; 95% CI: 5.7 - 492.6). This is one of the few studies showing IR and RRRs of acute HCV infections and the first focused on a large city in Spain. Sexual risk for transmission between men, higher educational level and HIV co-infection are important factors for understanding current HCV epidemic. There has been a partial shift in the pattern of the risk factor for transmission from nosocomial to sexual.

Original languageEnglish (US)
Article numbere0187893
JournalPLoS One
Volume12
Issue number11
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

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Hepatitis C virus
Virus Diseases
Viruses
Hepacivirus
relative risk
incidence
confidence interval
infection
Confidence Intervals
Incidence
risk factors
Odds Ratio
HIV
educational status
Coinfection
mixed infection
Spain
HIV Infections
Logistics
Cohort Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Garriga, C., Manzanares-Laya, S., García De Olalla, P., Gorrindo, P., Lens, S., Solà, R., ... Caylà, J. A. (2017). Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns. PLoS One, 12(11), [e0187893]. https://doi.org/10.1371/journal.pone.0187893

Evolution of acute hepatitis C virus infection in a large European city : Trends and new patterns. / Garriga, César; Manzanares-Laya, Sandra; García De Olalla, Patricia; Gorrindo, Pilar; Lens, Sabela; Solà, Ricard; Martínez-Rebollar, María; Laguno, Montserrat; Navarro, Jordi; Torras, Xavier; Gurguí, Mercè; Barberá, María Jesús; Quer, Josep; Masdeu, Eva; Simón, Pere; Ros, Miriam; De Andrés, Anna; Caylà, Joan A.

In: PLoS One, Vol. 12, No. 11, e0187893, 01.11.2017.

Research output: Contribution to journalArticle

Garriga, C, Manzanares-Laya, S, García De Olalla, P, Gorrindo, P, Lens, S, Solà, R, Martínez-Rebollar, M, Laguno, M, Navarro, J, Torras, X, Gurguí, M, Barberá, MJ, Quer, J, Masdeu, E, Simón, P, Ros, M, De Andrés, A & Caylà, JA 2017, 'Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns', PLoS One, vol. 12, no. 11, e0187893. https://doi.org/10.1371/journal.pone.0187893
Garriga C, Manzanares-Laya S, García De Olalla P, Gorrindo P, Lens S, Solà R et al. Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns. PLoS One. 2017 Nov 1;12(11). e0187893. https://doi.org/10.1371/journal.pone.0187893
Garriga, César ; Manzanares-Laya, Sandra ; García De Olalla, Patricia ; Gorrindo, Pilar ; Lens, Sabela ; Solà, Ricard ; Martínez-Rebollar, María ; Laguno, Montserrat ; Navarro, Jordi ; Torras, Xavier ; Gurguí, Mercè ; Barberá, María Jesús ; Quer, Josep ; Masdeu, Eva ; Simón, Pere ; Ros, Miriam ; De Andrés, Anna ; Caylà, Joan A. / Evolution of acute hepatitis C virus infection in a large European city : Trends and new patterns. In: PLoS One. 2017 ; Vol. 12, No. 11.
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