TY - JOUR
T1 - Evolution of acute hepatitis C virus infection in a large European city
T2 - Trends and new patterns
AU - Garriga, César
AU - Manzanares-Laya, Sandra
AU - García De Olalla, Patricia
AU - Gorrindo, Pilar
AU - Lens, Sabela
AU - Solà, Ricard
AU - Martínez-Rebollar, María
AU - Laguno, Montserrat
AU - Navarro, Jordi
AU - Torras, Xavier
AU - Gurguí, Mercè
AU - Barberá, María Jesús
AU - Quer, Josep
AU - Masdeu, Eva
AU - Simón, Pere
AU - Ros, Miriam
AU - De Andrés, Anna
AU - Caylà, Joan A.
N1 - Publisher Copyright:
© 2017 Garriga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/11
Y1 - 2017/11
N2 - The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases were grouped between 2004–2005, 2006–2011 and 2012–2015, and their incidence rate ratios (IRR) were calculated. In addition, risk factors for acute HCV infection were identified using multinomial logistic regression for complete, available and multiple imputed data. 204 new HCV cases were identified. Two peaks of higher IR of acute HCV infection in 2005 and 2013 were observed. Men and those aged 35–54 had higher IR. IRR for men was 2.9 times greater than in women (95% confidence intervals (CI): 1.8 - 4.7). Factors related to the period 2012–2015 (versus 2006–2011) were: a) sexual risk factor for transmission versus nosocomial (relative-risk ratio (RRR): 13.0; 95% CI: 2.3 - 72.1), b) higher educated versus lower (RRR: 5.4; 95% CI: 1.6 - 18.7), and c) HIV coinfected versus not HIV-infected (RRR: 53.1; 95% CI: 5.7 - 492.6). This is one of the few studies showing IR and RRRs of acute HCV infections and the first focused on a large city in Spain. Sexual risk for transmission between men, higher educational level and HIV co-infection are important factors for understanding current HCV epidemic. There has been a partial shift in the pattern of the risk factor for transmission from nosocomial to sexual.
AB - The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases were grouped between 2004–2005, 2006–2011 and 2012–2015, and their incidence rate ratios (IRR) were calculated. In addition, risk factors for acute HCV infection were identified using multinomial logistic regression for complete, available and multiple imputed data. 204 new HCV cases were identified. Two peaks of higher IR of acute HCV infection in 2005 and 2013 were observed. Men and those aged 35–54 had higher IR. IRR for men was 2.9 times greater than in women (95% confidence intervals (CI): 1.8 - 4.7). Factors related to the period 2012–2015 (versus 2006–2011) were: a) sexual risk factor for transmission versus nosocomial (relative-risk ratio (RRR): 13.0; 95% CI: 2.3 - 72.1), b) higher educated versus lower (RRR: 5.4; 95% CI: 1.6 - 18.7), and c) HIV coinfected versus not HIV-infected (RRR: 53.1; 95% CI: 5.7 - 492.6). This is one of the few studies showing IR and RRRs of acute HCV infections and the first focused on a large city in Spain. Sexual risk for transmission between men, higher educational level and HIV co-infection are important factors for understanding current HCV epidemic. There has been a partial shift in the pattern of the risk factor for transmission from nosocomial to sexual.
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U2 - 10.1371/journal.pone.0187893
DO - 10.1371/journal.pone.0187893
M3 - Article
C2 - 29135988
AN - SCOPUS:85033784984
SN - 1932-6203
VL - 12
JO - PloS one
JF - PloS one
IS - 11
M1 - e0187893
ER -