Evolution and dynamics of pancreatic cancer progression

S. Yachida, C. A. Iacobuzio-Donahue

Research output: Contribution to journalReview articlepeer-review

Abstract

Efficient metastasis is believed as the result of multiple genetic, epigenetic and/or post-translational events in the lifetime of a carcinoma. At the genetic level, these events may be categorized into those that occur during carcinogenesis, and those that occur during subclonal evolution. This review summarizes current knowledge of the genetics of pancreatic cancer from its initiation within a normal cell until the time that is has disseminated to distant organs, many features of which can be extrapolated to other solid tumor types. The implications of these findings to personalize genome analyses of an individual patient's tumor are also discussed.

Original languageEnglish (US)
Pages (from-to)5253-5260
Number of pages8
JournalOncogene
Volume32
Issue number45
DOIs
StatePublished - Nov 7 2013

Keywords

  • clonal evolution
  • genetics
  • metastasis
  • pancreatic cancer

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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