TY - JOUR
T1 - Evidence that protection against rotavirus diarrhea after natural infection is not dependent on serotype-specific neutralizing antibody
AU - Ward, Richard L.
AU - Clemens, John D.
AU - Knowlton, Douglas R.
AU - Rao, Malla R.
AU - Van Loon, Frederik P.L.
AU - Huda, Nurul
AU - Ahmed, Faruque
AU - Schiff, Gilbert M.
AU - Sack, David A.
N1 - Funding Information:
Received I April 1992; revised 22 July 1992. Informed consent was obtained from the parents or guardians of study subjects. Financial support: US Agency for International Development (contract 282-90-0019). Reprints or correspondence: Dr. Richard L. Ward, J. N. Gamble Institute of Medical Research, 2141 Auburn Ave., Cincinnati, OH 45219.
PY - 1992
Y1 - 1992
N2 - This case-control study sought to determine whether protection against clinically significant rotavirus diarrhea in children aged 4-35 months correlated with titers of serum neutralizing antibody and, if so, whether this protection was serotype-specific. Titers of acute-phase sera from 156 cases of treated rotavirus diarrhea in rural Bangladesh were contrasted with titers from 312 contemporaneously selected, age-matched controls. Analyses of the culture-adapted rotaviruses from the cases revealed that 24%, 15%, 43%, and 17% belonged to serotypes 1-4, respectively. Titers of both homologous and heterologous neutralizing antibody in acute blood specimens of cases were significantly lower than those of matched controls. However, multivariate logistic regression models demonstrated that only antibody titers to heterotypic rotaviruses were independently associated with protection against rotavirus disease. These data, which indicate that the correlation of protection with neutralizing antibody titers is not serotype-specific, suggest that immunity to rotavirus disease may be mediated by other factors.
AB - This case-control study sought to determine whether protection against clinically significant rotavirus diarrhea in children aged 4-35 months correlated with titers of serum neutralizing antibody and, if so, whether this protection was serotype-specific. Titers of acute-phase sera from 156 cases of treated rotavirus diarrhea in rural Bangladesh were contrasted with titers from 312 contemporaneously selected, age-matched controls. Analyses of the culture-adapted rotaviruses from the cases revealed that 24%, 15%, 43%, and 17% belonged to serotypes 1-4, respectively. Titers of both homologous and heterologous neutralizing antibody in acute blood specimens of cases were significantly lower than those of matched controls. However, multivariate logistic regression models demonstrated that only antibody titers to heterotypic rotaviruses were independently associated with protection against rotavirus disease. These data, which indicate that the correlation of protection with neutralizing antibody titers is not serotype-specific, suggest that immunity to rotavirus disease may be mediated by other factors.
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U2 - 10.1093/infdis/166.6.1251
DO - 10.1093/infdis/166.6.1251
M3 - Article
C2 - 1331249
AN - SCOPUS:0026445354
SN - 0022-1899
VL - 166
SP - 1251
EP - 1257
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -