Evidence that protection against rotavirus diarrhea after natural infection is not dependent on serotype-specific neutralizing antibody

Richard L. Ward, John D. Clemens, Douglas R. Knowlton, Malla R. Rao, Frederik P.L. Van Loon, Nurul Huda, Faruque Ahmed, Gilbert M. Schiff, David A. Sack

Research output: Contribution to journalArticle

Abstract

This case-control study sought to determine whether protection against clinically significant rotavirus diarrhea in children aged 4-35 months correlated with titers of serum neutralizing antibody and, if so, whether this protection was serotype-specific. Titers of acute-phase sera from 156 cases of treated rotavirus diarrhea in rural Bangladesh were contrasted with titers from 312 contemporaneously selected, age-matched controls. Analyses of the culture-adapted rotaviruses from the cases revealed that 24%, 15%, 43%, and 17% belonged to serotypes 1-4, respectively. Titers of both homologous and heterologous neutralizing antibody in acute blood specimens of cases were significantly lower than those of matched controls. However, multivariate logistic regression models demonstrated that only antibody titers to heterotypic rotaviruses were independently associated with protection against rotavirus disease. These data, which indicate that the correlation of protection with neutralizing antibody titers is not serotype-specific, suggest that immunity to rotavirus disease may be mediated by other factors.

Original languageEnglish (US)
Pages (from-to)1251-1257
Number of pages7
JournalJournal of Infectious Diseases
Volume166
Issue number6
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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