Evidence that mismatched bases in heteroduplex T4 bacteriophage are recognized in vivo

H. Berger, D. Pardoll

Research output: Contribution to journalArticlepeer-review

Abstract

T4 heteroduplex heterozygotes are lost selectively after prolonged incubation of phage infected E. coli cells under nonreplicating conditions. The loss of heterozygosity occurs for 4 out of 6 rII sites tested and is not dependent upon T4 v gene function. The results are interpreted to indicate the existence of a base specific system for the recognition of mismatched bases in intracellular DNA.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalJournal of virology
Volume20
Issue number2
DOIs
StatePublished - 1976

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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