T4 heteroduplex heterozygotes are lost selectively after prolonged incubation of phage infected E. coli cells under nonreplicating conditions. The loss of heterozygosity occurs for 4 out of 6 rII sites tested and is not dependent upon T4 v gene function. The results are interpreted to indicate the existence of a base specific system for the recognition of mismatched bases in intracellular DNA.
ASJC Scopus subject areas
- Insect Science