@article{724b923ae84c44dea7820372da5655cc,
title = "Evidence that inactivated oral cholera vaccines both prevent and mitigate Vibrio cholerae Ol infections in a cholera-endemic area",
abstract = "In a randomized, placebo-controlled field trial of B subunit-killed whole cell (BS-WC) and killed whole cell only (WC) inactivated oral cholera vaccines in rural Bangladesh, active surveillance of selected neighborhoods during the first year after vaccination identified 127 Vibrio cholerae O1 infections among 3285 three-dose recipients. For each vaccine, protective efficacy was greater against symptomatic (57%, P <.05 for BS-WC; 58%, P <.05 for WC) than against asymptomatic infections (46%, P <.05 for BS-WC; 32%, P =.09 for WC), and protection against each grade of infection was demonstrable for both the classical and E1 Tor biotypes. Although vaccine protection against symptomatic infections was evident in both young children and older persons, only persons vaccinated at age >5 years were protected against asymptomatic infections. These results suggest that the inactivated oral vaccines acted both to protect against intestinal colonization by V. cholerae O1 and to interrupt the pathogenic sequence of established infections.",
author = "Clemens, {John D.} and Sack, {David A.} and Rao, {Malia R.} and J. Chakraborty and Khan, {M. R.} and Bradford Kay and F. Ahmed and Banik, {A. K.} and {van Loon}, {F. P.L.} and M. Yunus and Harris, {Jeffrey R.}",
note = "Funding Information: Received 10 April 1992; revised 22 June 1992. All subjects or their parents or guardians gave informed consent. Financial support: United Agency for International Development. World Health Organization (WHO), Swedish Agency for Research Cooperation with Developing Countries (SAREC), and government ofJapan. ICDDR,B is supported by countries and agencies that share its concerns; current donors include Arab Gulf Programme. Australia. Bangladesh. Belgium. Canada. Denmark, Ford Foundation, France. Japan. Norwegian Agency for International Development. Saudi Arabia. SAREC, Switzerland. United Kingdom. United Nations (UN) International Children's Fund. UN Development Program. US Agency for International Development. World Bank, and WHO. Reprints or correspondence: Dr. John Clemens. Division of Epidemiology. Statistics. and Prevention Research. National Institute ofChild Health and Human Development. Rm. 640, Executive Plaza N.• Bethesda. MD 20892. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",
year = "1992",
month = nov,
doi = "10.1093/infdis/166.5.1029",
language = "English (US)",
volume = "166",
pages = "1029--1034",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",
}