Evidence that glyburide-induced diuresis is not mediated by inhibition of ADH

Arnold M. Moses, Marcia van Gemert, Myron Miller

Research output: Contribution to journalArticle

Abstract

The sulfonylurea, chlorpropamide, has a well defined antidiuretic effect mediated both through increased ADH release and potentiation of ADH action on the kidney. In contrast, the sulfonylureas tolazamide, acetohexamide and glyburide have diuretic actions. The diuretic actions of glyburide is not mediated through inhibition of ADH release or interference with the renal action of ADH. Therefore glyburide, and presumably the other diuretic sulfonylureas, apparently have diuretic actions by means of a direct renal effect, perhaps by altering renal hemodynamics or by acting on the renal tubule.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalHormone Research in Paediatrics
Volume5
Issue number6
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

Keywords

  • ADH
  • Diabetes insipidus
  • Diuresis
  • Glyburide

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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