Evidence that excitatory amino acids mediate afferent input to the primate somatosensory thalamus

P. M. Dougherty, Y. J. Li, F. A. Lenz, L. Rowland, S. Mittman

Research output: Contribution to journalArticlepeer-review

Abstract

Neurons in and posterior to the primate sensory nucleus of the thalamus (VPL) were tested for excitation by iontophoretically applied excitatory amino acid agonists. In addition, in several cells the effects of iontophoretically applied excitatory amino acid antagonists on the responses to cutaneous stimuli were examined. All neurons showed responses to all agonists. The responses of several neurons to cutaneous stimuli were attenuated or blocked by local administration of receptor antagonists. These results provide initial evidence that somatosensory responses of neurons in the primate thalamus are mediated by excitatory amino acids.

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalBrain research
Volume728
Issue number2
DOIs
StatePublished - Jul 29 1996

Keywords

  • AMPA
  • Glutamate
  • Kainate
  • Microiontophoresis
  • Monkey
  • NMDA
  • Neurotransmission
  • Pain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Evidence that excitatory amino acids mediate afferent input to the primate somatosensory thalamus'. Together they form a unique fingerprint.

Cite this