TY - JOUR
T1 - Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo
AU - Koliatsos, Vassilis E.
AU - Clatterbuck, Richard E.
AU - Winslow, John W.
AU - Cayouette, Michelle H.
AU - Prices, Donald L.
N1 - Funding Information:
Theauthors thank Drs. GeorgeYancopoulos and Louis Reichardt who provided the rat trkB and mouse NGF cDNA, respectively. Antibody 192-IgG was generated from a cell line provided by Dr. EugeneJohnson (Washington University, St. Louis, MO). Human recombinant NGF,BDNF,and NT-3wereagiftfromTheResearch Collaborations Program at Cenentech, Inc. (South San Francisco, CA). Ms. Catherine Fleischman performed the quantitativeanaly-sis of the facial axotomy experiments. The work was supported by grants from the US Public Health Service (NS20471, AG05146, and NS07179), as well as the American Health Assistance Foundation and the Metropolitan Life Foundation. V. E. K. and D. L. P. are the recipients of a Leadership and Excellence in Alzheimer’s Disease (LEAD) award (AC07914). D. L. P. is also the recipient of a Javits Neuroscience Investigator Award (NS10580). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 17345 solely to indicate this fact.
PY - 1993/3
Y1 - 1993/3
N2 - The neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) act upon populations of neurons that express specific receptors. The present study demonstrates that BDNF rescues motor neurons from degeneration and may also play a role in the normal physiology of these cells. BDNF is expressed in the local environment and in muscle targets of motor neurons; muscle expression is up-regulated by denervation. The a motor neurons express the gene encoding p145trkB, a receptor involved in BDNF signal transduction, whereas a subset of motor neurons express p75NGFR. BDNF is transported selectively to α motor neurons from skeletal muscles. Finally, BDNF prevents motor neuron death in the axotomized facial nucleus of the neonatal rat. The effects of BDNF on motor neurons raise the possibility that some neurotrophins may be useful in treating patients with motor neuropathies and amyotrophic lateral sclerosis.
AB - The neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) act upon populations of neurons that express specific receptors. The present study demonstrates that BDNF rescues motor neurons from degeneration and may also play a role in the normal physiology of these cells. BDNF is expressed in the local environment and in muscle targets of motor neurons; muscle expression is up-regulated by denervation. The a motor neurons express the gene encoding p145trkB, a receptor involved in BDNF signal transduction, whereas a subset of motor neurons express p75NGFR. BDNF is transported selectively to α motor neurons from skeletal muscles. Finally, BDNF prevents motor neuron death in the axotomized facial nucleus of the neonatal rat. The effects of BDNF on motor neurons raise the possibility that some neurotrophins may be useful in treating patients with motor neuropathies and amyotrophic lateral sclerosis.
UR - http://www.scopus.com/inward/record.url?scp=0027481752&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027481752&partnerID=8YFLogxK
U2 - 10.1016/0896-6273(93)90326-M
DO - 10.1016/0896-6273(93)90326-M
M3 - Article
C2 - 8080464
AN - SCOPUS:0027481752
SN - 0896-6273
VL - 10
SP - 359
EP - 367
JO - Neuron
JF - Neuron
IS - 3
ER -