Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing

S. S. Sisodia, E. H. Koo, K. Beyreuther, A. Unterbeck, D. L. Price

Research output: Contribution to journalArticle

Abstract

The β-amyloid protein (β/A4), derived from a larger amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. APP is an integral membrane glycoprotein and is secreted as a carboxyl-terminal truncated molecule. APP cleavage, which is a membrane-associated event, occurred at a site located within the β/A4 region. This suggests that an intact amyloidogenic β/A4 fragment is not generated during normal APP catabolism. Therefore, an early event in amyloid formation may involve altered APP processing that results in the release and subsequent deposition of intact β/A4.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalScience
Volume248
Issue number4954
StatePublished - Apr 27 1990

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Amyloidogenic Proteins
Amyloid beta-Protein Precursor
Alzheimer Disease
Amyloid beta-Peptides
Membrane Glycoproteins
Amyloid Plaques
Amyloid
Membranes

ASJC Scopus subject areas

  • General

Cite this

Sisodia, S. S., Koo, E. H., Beyreuther, K., Unterbeck, A., & Price, D. L. (1990). Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. Science, 248(4954), 492-495.

Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. / Sisodia, S. S.; Koo, E. H.; Beyreuther, K.; Unterbeck, A.; Price, D. L.

In: Science, Vol. 248, No. 4954, 27.04.1990, p. 492-495.

Research output: Contribution to journalArticle

Sisodia, SS, Koo, EH, Beyreuther, K, Unterbeck, A & Price, DL 1990, 'Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing', Science, vol. 248, no. 4954, pp. 492-495.
Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL. Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. Science. 1990 Apr 27;248(4954):492-495.
Sisodia, S. S. ; Koo, E. H. ; Beyreuther, K. ; Unterbeck, A. ; Price, D. L. / Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. In: Science. 1990 ; Vol. 248, No. 4954. pp. 492-495.
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