Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing

S. S. Sisodia, E. H. Koo, K. Beyreuther, A. Unterbeck, D. L. Price

Research output: Contribution to journalArticlepeer-review

Abstract

The β-amyloid protein (β/A4), derived from a larger amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. APP is an integral membrane glycoprotein and is secreted as a carboxyl-terminal truncated molecule. APP cleavage, which is a membrane-associated event, occurred at a site located within the β/A4 region. This suggests that an intact amyloidogenic β/A4 fragment is not generated during normal APP catabolism. Therefore, an early event in amyloid formation may involve altered APP processing that results in the release and subsequent deposition of intact β/A4.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalScience
Volume248
Issue number4954
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • General

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