Evidence of the Peripheral Inflammatory Response in Patients With Transient Ischemic Attack

Amy Miner Ross, Patricia Hurn, Nancy A Perrin, Lisa Wood, Walter Carlini, Kathleen Potempa

Research output: Contribution to journalArticle

Abstract

The peripheral inflammatory response, as a proxy for the acute-phase response (a known mechanism for ischemic preconditioning), and non-damage-producing transient ischemia must exist together in humans if this candidate mechanism confers ischemic tolerance. The present study was aimed at determining whether the peripheral inflammatory response (ie, elevated white blood cell, neutrophil, and monocyte counts) exists in transient ischemic attack (TIA) and stroke patients at the time of emergency room admission. The null hypothesis was tested for the variables of the peripheral inflammatory response between the mean of the laboratory normal population versus stroke and TIA patients. A retrospective review of 1041 medical records yielded 12 first-time TIA patients and 34 first-time stroke patients with no confounding evidence of other inflammatory processes. In both groups, neutrophil and monocyte percentages were significantly higher than the laboratory means (in TIA cases: neutrophils, 67.9% [12.67%], P = .001; monocytes, 8.2% [2.7%], P = .020; in stroke cases: neutrophils, 64.9% [9.1%], monocytes, 7.7% [1.6%]; both P <.001). Absolute neutrophil count was significantly higher than the laboratory mean for the stroke cases (5.13 [1.88] K/UL; P = .022). Lymphocyte percentages and absolute lymphocyte count in both groups were significantly and abnormally lower than the laboratory mean (in TIA cases, 21.7% [10.5%] and 1.4 [0.6] K/UL, respectively; in stroke cases, 24.7% [8.4%] and 1.9 [0.7] K/UL, respectively; all P ≤ .001). No other absolute counts were significant. These findings suggest that the peripheral inflammatory response exists in transient ischemia, which hypothetically does not damage brain tissue, as well as in stroke (or permanent ischemia), which is known to produce brain tissue damage.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalJournal of Stroke and Cerebrovascular Diseases
Volume16
Issue number5
DOIs
StatePublished - Sep 2007
Externally publishedYes

Fingerprint

Transient Ischemic Attack
Stroke
Neutrophils
Monocytes
Ischemia
Ischemic Preconditioning
Acute-Phase Reaction
Brain
Lymphocyte Count
Proxy
Medical Records
Hospital Emergency Service
Leukocytes
Lymphocytes
Population

Keywords

  • acute phase response
  • Inflammatory response
  • transient ischemic attacks

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Health Professions(all)

Cite this

Evidence of the Peripheral Inflammatory Response in Patients With Transient Ischemic Attack. / Ross, Amy Miner; Hurn, Patricia; Perrin, Nancy A; Wood, Lisa; Carlini, Walter; Potempa, Kathleen.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 16, No. 5, 09.2007, p. 203-207.

Research output: Contribution to journalArticle

Ross, Amy Miner ; Hurn, Patricia ; Perrin, Nancy A ; Wood, Lisa ; Carlini, Walter ; Potempa, Kathleen. / Evidence of the Peripheral Inflammatory Response in Patients With Transient Ischemic Attack. In: Journal of Stroke and Cerebrovascular Diseases. 2007 ; Vol. 16, No. 5. pp. 203-207.
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