Evidence of thalamic gray matter loss in pediatric multiple sclerosis

S. Mesaros, M. A. Rocca, Martina Absinta, A. Ghezzi, N. Milani, L. Moiola, P. Veggiotti, G. Comi, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

Objective: We used voxel-based morphometry (VBM) to assess the pattern of regional gray matter (GM) loss in patients with pediatric multiple sclerosis (MS) and its relation with the Expanded Disability Status Scale (EDSS) score, disease duration, and the extent of T2 lesion load (LL). Methods: From 28 patients with pediatric relapsing-remitting MS (16 girls; mean age = 14.4 years, range = 7 to 16 years) and 21 matched controls, dual-echo and three-dimensional T1-weighted magnetization prepared rapid acquisition gradient echo sequences were acquired. T2 LL was measured using a local thresholding segmentation technique. Data were analyzed using an optimized VBM analysis and statistical parametric mapping. Results: In pediatric patients with MS, mean brain T2 LL was 7.8 mL = 11.3. Intracranial volume did not differ between patients and controls. Compared to controls, patients with pediatric MS had significant GM loss in the thalamus, bilaterally, which was significantly correlated with T2 LL (r=-0.80 for the right thalamus, r=-0.74 for the left thalamus, p < 0.05, corrected for multiple comparisons). No correlation was found between thalamic GM loss, disease duration, and disability. Conclusions: In patients with pediatric multiple sclerosis (MS), differently from what happens in adult-onset MS, gray matter (GM) atrophy seems to involve the thalamus only, with sparing of the cortex and other deep GM nuclei. The correlation found between atrophy and T2 lesion load suggests transsynaptic and Wallerian degenerations as the most likely substrate of tissue loss in the thalamus of these patients.

Original languageEnglish (US)
Pages (from-to)1107-1112
Number of pages6
JournalNeurology
Volume70
Issue number13 PART 2
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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Multiple Sclerosis
Thalamus
Pediatrics
Atrophy
Wallerian Degeneration
Relapsing-Remitting Multiple Sclerosis
Gray Matter
Brain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Mesaros, S., Rocca, M. A., Absinta, M., Ghezzi, A., Milani, N., Moiola, L., ... Filippi, M. (2008). Evidence of thalamic gray matter loss in pediatric multiple sclerosis. Neurology, 70(13 PART 2), 1107-1112. https://doi.org/10.1212/01.wnl.0000291010.54692.85

Evidence of thalamic gray matter loss in pediatric multiple sclerosis. / Mesaros, S.; Rocca, M. A.; Absinta, Martina; Ghezzi, A.; Milani, N.; Moiola, L.; Veggiotti, P.; Comi, G.; Filippi, Massimo.

In: Neurology, Vol. 70, No. 13 PART 2, 01.01.2008, p. 1107-1112.

Research output: Contribution to journalArticle

Mesaros, S, Rocca, MA, Absinta, M, Ghezzi, A, Milani, N, Moiola, L, Veggiotti, P, Comi, G & Filippi, M 2008, 'Evidence of thalamic gray matter loss in pediatric multiple sclerosis', Neurology, vol. 70, no. 13 PART 2, pp. 1107-1112. https://doi.org/10.1212/01.wnl.0000291010.54692.85
Mesaros S, Rocca MA, Absinta M, Ghezzi A, Milani N, Moiola L et al. Evidence of thalamic gray matter loss in pediatric multiple sclerosis. Neurology. 2008 Jan 1;70(13 PART 2):1107-1112. https://doi.org/10.1212/01.wnl.0000291010.54692.85
Mesaros, S. ; Rocca, M. A. ; Absinta, Martina ; Ghezzi, A. ; Milani, N. ; Moiola, L. ; Veggiotti, P. ; Comi, G. ; Filippi, Massimo. / Evidence of thalamic gray matter loss in pediatric multiple sclerosis. In: Neurology. 2008 ; Vol. 70, No. 13 PART 2. pp. 1107-1112.
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AU - Absinta, Martina

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AU - Milani, N.

AU - Moiola, L.

AU - Veggiotti, P.

AU - Comi, G.

AU - Filippi, Massimo

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