Evidence of structural remodeling in the dyssynchronous failing heart

Patrick A. Helm, Laurent Younes, Mirza F. Beg, Daniel B. Ennis, Christophe Leclercq, Owen P. Faris, Elliot McVeigh, David Kass, Michael I. Miller, Raimond L. Winslow

Research output: Contribution to journalArticle

Abstract

Ventricular remodeling of both geometry and fiber structure is a prominent feature of several cardiac pathologies. Advances in MRI and analytical methods now make it possible to measure changes of cardiac geometry, fiber, and sheet orientation at high spatial resolution. In this report, we use diffusion tensor imaging to measure the geometry, fiber, and sheet architecture of eight normal and five dyssynchronous failing canine hearts, which were explanted and fixed in an unloaded state. We apply novel computational methods to identify statistically significant changes of cardiac anatomic structure in the failing and control heart populations. The results demonstrate significant regional differences in geometric remodeling in the dyssynchronous failing heart versus control. Ventricular chamber dilatation and reduction in wall thickness in septal and some posterior and anterior regions are observed. Primary fiber orientation showed no significant change. However, this result coupled with the local wall thinning in the septum implies an altered transmural fiber gradient. Further, we observe that orientation of laminar sheets become more vertical in the early-activated septum, with no significant change of sheet orientation in the late-activated lateral wall. Measured changes in both fiber gradient and sheet structure will affect both the heterogeneity of passive myocardial properties as well as electrical activation of the ventricles.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalCirculation research
Volume98
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Cardiac remodeling
  • Computational anatomy
  • Dyssynchrony
  • Fiber architecture

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Helm, P. A., Younes, L., Beg, M. F., Ennis, D. B., Leclercq, C., Faris, O. P., McVeigh, E., Kass, D., Miller, M. I., & Winslow, R. L. (2006). Evidence of structural remodeling in the dyssynchronous failing heart. Circulation research, 98(1), 125-132. https://doi.org/10.1161/01.RES.0000199396.30688.eb