Evidence of MAOA genotype involvement in spatial ability in males

Sven C. Mueller, Brian R. Cornwell, Christian Grillon, Jessica MacIntyre, Elena Gorodetsky, David Goldman, Daniel S. Pine, Monique Ernst

Research output: Contribution to journalArticle

Abstract

Although the monoamine oxidase-A (MAOA) gene has been linked to spatial learning and memory in animal models, convincing evidence in humans is lacking. Performance on an ecologically-valid, virtual computer-based equivalent of the Morris Water Maze task was compared between 28 healthy males with the low MAOA transcriptional activity and 41 healthy age- and IQ-matched males with the high MAOA transcriptional activity. The results revealed consistently better performance (reduced heading error, shorter path length, and reduced failed trials) for the high MAOA activity individuals relative to the low activity individuals. By comparison, groups did not differ on pre-task variables or strategic measures such as first-move latency. The results provide novel evidence of MAOA gene involvement in human spatial navigation using a virtual analogue of the Morris Water Maze task.

Original languageEnglish (US)
Pages (from-to)106-110
Number of pages5
JournalBehavioural Brain Research
Volume267
DOIs
StatePublished - Jul 1 2014
Externally publishedYes

Fingerprint

Monoamine Oxidase
Genotype
Water
Genes
Animal Models
Spatial Navigation

Keywords

  • Gene
  • Learning
  • Monoamine-oxidase
  • Spatial memory
  • Spatial navigation
  • Virtual maze

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Medicine(all)

Cite this

Mueller, S. C., Cornwell, B. R., Grillon, C., MacIntyre, J., Gorodetsky, E., Goldman, D., ... Ernst, M. (2014). Evidence of MAOA genotype involvement in spatial ability in males. Behavioural Brain Research, 267, 106-110. https://doi.org/10.1016/j.bbr.2014.03.025

Evidence of MAOA genotype involvement in spatial ability in males. / Mueller, Sven C.; Cornwell, Brian R.; Grillon, Christian; MacIntyre, Jessica; Gorodetsky, Elena; Goldman, David; Pine, Daniel S.; Ernst, Monique.

In: Behavioural Brain Research, Vol. 267, 01.07.2014, p. 106-110.

Research output: Contribution to journalArticle

Mueller, SC, Cornwell, BR, Grillon, C, MacIntyre, J, Gorodetsky, E, Goldman, D, Pine, DS & Ernst, M 2014, 'Evidence of MAOA genotype involvement in spatial ability in males', Behavioural Brain Research, vol. 267, pp. 106-110. https://doi.org/10.1016/j.bbr.2014.03.025
Mueller SC, Cornwell BR, Grillon C, MacIntyre J, Gorodetsky E, Goldman D et al. Evidence of MAOA genotype involvement in spatial ability in males. Behavioural Brain Research. 2014 Jul 1;267:106-110. https://doi.org/10.1016/j.bbr.2014.03.025
Mueller, Sven C. ; Cornwell, Brian R. ; Grillon, Christian ; MacIntyre, Jessica ; Gorodetsky, Elena ; Goldman, David ; Pine, Daniel S. ; Ernst, Monique. / Evidence of MAOA genotype involvement in spatial ability in males. In: Behavioural Brain Research. 2014 ; Vol. 267. pp. 106-110.
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