Evidence of genetic susceptibility to infectious mononucleosis: A twin study

A. E. Hwang, A. S. Hamilton, M. G. Cockburn, R. Ambinder, J. Zadnick, E. E. Brown, T. M. MacK, W. Cozen

Research output: Contribution to journalArticlepeer-review

Abstract

Infectious mononucleosis is a clinical manifestation of primary Epstein-Barr virus infection. It is unknown whether genetic factors contribute to risk. To assess heritability, we compared disease concordance in monozygotic to dizygotic twin pairs from the population-based California Twin Program and assessed the risk to initially unaffected co-twins. One member of 611 and both members of 58 twin pairs reported a history of infectious mononucleosis. Pairwise concordance in monozygotic and dizygotic pairs was respectively 121% [standard error (s.e.)=19%] and 61% (s.e.=12%). The relative risk (hazard ratio) of monozygotic compared to dizygotic unaffected co-twins of cases was 19 [95% confidence interval (CI) 11-34, P=003], over the follow-up period. When the analysis was restricted to same-sex twin pairs, that estimate was 25 (95% CI 12-53, P=002). The results are compatible with a heritable contribution to the risk of infectious mononucleosis.

Original languageEnglish (US)
Pages (from-to)2089-2095
Number of pages7
JournalEpidemiology and infection
Volume140
Issue number11
DOIs
StatePublished - Nov 2012

Keywords

  • Epstein-Barr virus
  • genetics
  • infectious mononucleosis
  • twins

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

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