Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

Jielin Sun, Siqun Lilly Zheng, Fredrik Wiklund, Sarah D. Isaacs, Lina D. Purcell, Zhengrong Gao, Fang Chi Hsu, Seong Tae Kim, Wennuan Liu, Yi Zhu, Pär Stattin, Hans Olov Adami, Kathleen E. Wiley, Latchezar Dimitrov, Jishan Sun, Tao Li, Aubrey R. Turner, Tamara S. Adams, Jan Adolfsson, Jan Erik JohanssonJames Lowey, Bruce J. Trock, Alan W. Partin, Patrick C. Walsh, Jeffrey M. Trent, David Duggan, John Carpten, Bao Li Chang, Henrik Grönberg, William B. Isaacs, Jianfeng Xu

Research output: Contribution to journalArticle

Abstract

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

Original languageEnglish (US)
Pages (from-to)1153-1155
Number of pages3
JournalNature genetics
Volume40
Issue number10
DOIs
StatePublished - Oct 2008

ASJC Scopus subject areas

  • Genetics

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    Sun, J., Zheng, S. L., Wiklund, F., Isaacs, S. D., Purcell, L. D., Gao, Z., Hsu, F. C., Kim, S. T., Liu, W., Zhu, Y., Stattin, P., Adami, H. O., Wiley, K. E., Dimitrov, L., Sun, J., Li, T., Turner, A. R., Adams, T. S., Adolfsson, J., ... Xu, J. (2008). Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nature genetics, 40(10), 1153-1155. https://doi.org/10.1038/ng.214