Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

Jielin Sun, Siqun Lilly Zheng, Fredrik Wiklund, Sarah D. Isaacs, Lina D. Purcell, Zhengrong Gao, Fang Chi Hsu, Seong Tae Kim, Wennuan Liu, Yi Zhu, Pär Stattin, Hans Olov Adami, Kathleen E. Wiley, Latchezar Dimitrov, Jishan Sun, Tao Li, Aubrey R. Turner, Tamara S. Adams, Jan Adolfsson, Jan Erik JohanssonJames Lowey, Bruce Trock, Alan Wayne Partin, Patrick Walsh, Jeffrey M. Trent, David Duggan, John Carpten, Bao Li Chang, Henrik Grönberg, William B Isaacs, Jianfeng Xu

Research output: Contribution to journalArticle

Abstract

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

Original languageEnglish (US)
Pages (from-to)1153-1155
Number of pages3
JournalNature Genetics
Volume40
Issue number10
DOIs
StatePublished - Oct 2008

Fingerprint

Single Nucleotide Polymorphism
Prostatic Neoplasms
Genes
Genetic Recombination
Population

ASJC Scopus subject areas

  • Genetics

Cite this

Sun, J., Zheng, S. L., Wiklund, F., Isaacs, S. D., Purcell, L. D., Gao, Z., ... Xu, J. (2008). Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nature Genetics, 40(10), 1153-1155. https://doi.org/10.1038/ng.214

Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. / Sun, Jielin; Zheng, Siqun Lilly; Wiklund, Fredrik; Isaacs, Sarah D.; Purcell, Lina D.; Gao, Zhengrong; Hsu, Fang Chi; Kim, Seong Tae; Liu, Wennuan; Zhu, Yi; Stattin, Pär; Adami, Hans Olov; Wiley, Kathleen E.; Dimitrov, Latchezar; Sun, Jishan; Li, Tao; Turner, Aubrey R.; Adams, Tamara S.; Adolfsson, Jan; Johansson, Jan Erik; Lowey, James; Trock, Bruce; Partin, Alan Wayne; Walsh, Patrick; Trent, Jeffrey M.; Duggan, David; Carpten, John; Chang, Bao Li; Grönberg, Henrik; Isaacs, William B; Xu, Jianfeng.

In: Nature Genetics, Vol. 40, No. 10, 10.2008, p. 1153-1155.

Research output: Contribution to journalArticle

Sun, J, Zheng, SL, Wiklund, F, Isaacs, SD, Purcell, LD, Gao, Z, Hsu, FC, Kim, ST, Liu, W, Zhu, Y, Stattin, P, Adami, HO, Wiley, KE, Dimitrov, L, Sun, J, Li, T, Turner, AR, Adams, TS, Adolfsson, J, Johansson, JE, Lowey, J, Trock, B, Partin, AW, Walsh, P, Trent, JM, Duggan, D, Carpten, J, Chang, BL, Grönberg, H, Isaacs, WB & Xu, J 2008, 'Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12', Nature Genetics, vol. 40, no. 10, pp. 1153-1155. https://doi.org/10.1038/ng.214
Sun J, Zheng SL, Wiklund F, Isaacs SD, Purcell LD, Gao Z et al. Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nature Genetics. 2008 Oct;40(10):1153-1155. https://doi.org/10.1038/ng.214
Sun, Jielin ; Zheng, Siqun Lilly ; Wiklund, Fredrik ; Isaacs, Sarah D. ; Purcell, Lina D. ; Gao, Zhengrong ; Hsu, Fang Chi ; Kim, Seong Tae ; Liu, Wennuan ; Zhu, Yi ; Stattin, Pär ; Adami, Hans Olov ; Wiley, Kathleen E. ; Dimitrov, Latchezar ; Sun, Jishan ; Li, Tao ; Turner, Aubrey R. ; Adams, Tamara S. ; Adolfsson, Jan ; Johansson, Jan Erik ; Lowey, James ; Trock, Bruce ; Partin, Alan Wayne ; Walsh, Patrick ; Trent, Jeffrey M. ; Duggan, David ; Carpten, John ; Chang, Bao Li ; Grönberg, Henrik ; Isaacs, William B ; Xu, Jianfeng. / Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. In: Nature Genetics. 2008 ; Vol. 40, No. 10. pp. 1153-1155.
@article{9a7cceb37caf4e3a960a7debbf67b5ce,
title = "Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12",
abstract = "We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.",
author = "Jielin Sun and Zheng, {Siqun Lilly} and Fredrik Wiklund and Isaacs, {Sarah D.} and Purcell, {Lina D.} and Zhengrong Gao and Hsu, {Fang Chi} and Kim, {Seong Tae} and Wennuan Liu and Yi Zhu and P{\"a}r Stattin and Adami, {Hans Olov} and Wiley, {Kathleen E.} and Latchezar Dimitrov and Jishan Sun and Tao Li and Turner, {Aubrey R.} and Adams, {Tamara S.} and Jan Adolfsson and Johansson, {Jan Erik} and James Lowey and Bruce Trock and Partin, {Alan Wayne} and Patrick Walsh and Trent, {Jeffrey M.} and David Duggan and John Carpten and Chang, {Bao Li} and Henrik Gr{\"o}nberg and Isaacs, {William B} and Jianfeng Xu",
year = "2008",
month = "10",
doi = "10.1038/ng.214",
language = "English (US)",
volume = "40",
pages = "1153--1155",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

AU - Sun, Jielin

AU - Zheng, Siqun Lilly

AU - Wiklund, Fredrik

AU - Isaacs, Sarah D.

AU - Purcell, Lina D.

AU - Gao, Zhengrong

AU - Hsu, Fang Chi

AU - Kim, Seong Tae

AU - Liu, Wennuan

AU - Zhu, Yi

AU - Stattin, Pär

AU - Adami, Hans Olov

AU - Wiley, Kathleen E.

AU - Dimitrov, Latchezar

AU - Sun, Jishan

AU - Li, Tao

AU - Turner, Aubrey R.

AU - Adams, Tamara S.

AU - Adolfsson, Jan

AU - Johansson, Jan Erik

AU - Lowey, James

AU - Trock, Bruce

AU - Partin, Alan Wayne

AU - Walsh, Patrick

AU - Trent, Jeffrey M.

AU - Duggan, David

AU - Carpten, John

AU - Chang, Bao Li

AU - Grönberg, Henrik

AU - Isaacs, William B

AU - Xu, Jianfeng

PY - 2008/10

Y1 - 2008/10

N2 - We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

AB - We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

UR - http://www.scopus.com/inward/record.url?scp=52949115663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52949115663&partnerID=8YFLogxK

U2 - 10.1038/ng.214

DO - 10.1038/ng.214

M3 - Article

C2 - 18758462

AN - SCOPUS:52949115663

VL - 40

SP - 1153

EP - 1155

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -