Evidence for toxic precursors in illicit phencyclidine preparations

E. J. Cone, W. F. Buchwald, C. W. Gorodetzky, D. B. Vaupel

Research output: Contribution to journalArticle

Abstract

Piperidinocyclohexanecarbonitrile (PCC) is a toxic precursor of phencyclidine (PCP) and is employed in the illicit syntheses of PCP. Also, PCC and homologs are used for syntheses of other PCP derivatives. Conflicting reports on the presence of the cyclohexanecarbonitrile (CC) compound in street drug preparations led us to assess the toxicity of three precursors and to develop analytical methods for the detection and measurement of PCP precursors and homologs. Four hour acute LD50's (i.p., mg/kg) in male Swiss Webster mice were as follows: PCP 79.0; PCC, 29.0; pyrrolidino-CC, 36.5; morpholino-CC, 39.0. Analytical measurement of these compounds was made by gas chromatography (3% OV-17) with a nitrogen detector. The presence of about 0.5% of PCC in PCP preparations can be detected. Structural confirmation was made by methane chemical ionization mass spectrometry. All compounds (M) exhibited a unique (M+1)+, M+, (M-1)+ ion pattern by solid probe analysis. Analyses of 9 PCP street samples revealed the presence of PCC in 1 sample (2% of sample wt.). PCP content of tablets ranged from 1.1 - 6.8 mg, wherease powders contained 4.2 - 58.6%. Other components in the street samples were identified as sugars and steric and palmitic acid. N-ethyl-1-phenylcyclohexylamine and 1-[2-(2-thienyl)cyclohexyl]-piperidine also were identified in other street drug samples.

Original languageEnglish (US)
JournalFederation proceedings
Volume38
Issue number3 I
StatePublished - 1979
Externally publishedYes

Fingerprint

Phencyclidine
Poisons
Street Drugs
Morpholinos
Drug Compounding
Palmitic Acid
Lethal Dose 50
Methane
Gas Chromatography
Powders
Tablets
Mass Spectrometry
Nitrogen
Ions

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cone, E. J., Buchwald, W. F., Gorodetzky, C. W., & Vaupel, D. B. (1979). Evidence for toxic precursors in illicit phencyclidine preparations. Federation proceedings, 38(3 I).

Evidence for toxic precursors in illicit phencyclidine preparations. / Cone, E. J.; Buchwald, W. F.; Gorodetzky, C. W.; Vaupel, D. B.

In: Federation proceedings, Vol. 38, No. 3 I, 1979.

Research output: Contribution to journalArticle

Cone, EJ, Buchwald, WF, Gorodetzky, CW & Vaupel, DB 1979, 'Evidence for toxic precursors in illicit phencyclidine preparations', Federation proceedings, vol. 38, no. 3 I.
Cone EJ, Buchwald WF, Gorodetzky CW, Vaupel DB. Evidence for toxic precursors in illicit phencyclidine preparations. Federation proceedings. 1979;38(3 I).
Cone, E. J. ; Buchwald, W. F. ; Gorodetzky, C. W. ; Vaupel, D. B. / Evidence for toxic precursors in illicit phencyclidine preparations. In: Federation proceedings. 1979 ; Vol. 38, No. 3 I.
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