Evidence for the inactivation of an X chromosome early in the development of the human female

Barbara R Migeon, J. F. Kennedy

Research output: Contribution to journalArticle

Abstract

Studies of somatic tissues and cultured cells, including fibroblast clones, from human embryos heterozygous for the electrophoretic variants of glucose 6 phosphate dehydrogenase confirm that one X chromosome is inactivated very early in embryonic development and indicate that X inactivation has occurred in the majority of cells from a variety of tissues at least by 5 wk from conception.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalAmerican Journal of Human Genetics
Volume27
Issue number2
Publication statusPublished - 1975

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ASJC Scopus subject areas

  • Genetics

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