Evidence for the inactivation of an X chromosome early in the development of the human female

B. R. Migeon, J. F. Kennedy

Research output: Contribution to journalArticlepeer-review

Abstract

Studies of somatic tissues and cultured cells, including fibroblast clones, from human embryos heterozygous for the electrophoretic variants of glucose 6 phosphate dehydrogenase confirm that one X chromosome is inactivated very early in embryonic development and indicate that X inactivation has occurred in the majority of cells from a variety of tissues at least by 5 wk from conception.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalAmerican journal of human genetics
Volume27
Issue number2
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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