Evidence for ozone-induced small-airway dysfunction: Lack of menstrual-cycle and gender effects

Gail G. Weinmann, Margaret Weidenbach-Gerbase, William Michael Foster, Howard A Zacur, Robert Frank

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Abstract

Recently, we analyzed FEF25-75 isovolumetrically to assess the acute effects of ozone (O3) on smallairway function: the reduction in isovolumetric (isoV) FEF25-75 at end exposure progressed during the next 25 min even as FVC was recovering. To evaluate this effect over a longer period, we measured isovolumetric FEFs, helium-oxygen (He-O2) volume of isoflow (Visov̇), the multiple breath nitrogen washout (MBNW) curve, FRC, and RV in 24 subjects 24 h after a 130-min exposure to filtered air (FA) and O3 (0.35 ppm). Men and women were studied to test for gender-based differences in response, after first determining that menstrual-cycle phase did not itself influence response. Isovolumetric FEF25-75, V̇max50, and V̇max75 were reduced about equally at 25 min after O3 exposure (p ≤ 0.02) and showed no recovery at 24 h. FVC and FEV1, although still depressed after 24 h (p <0.05), showed substantial recovery (p <0.01). FRC, RV, and VisoV̇ showed no effect of O3 exposure. No gender differences in O3 responsiveness were found. In summary, O3-induced reductions in isovolumetric flow rates, suggestive of small-airway dysfunction, may persist for 24 h following acute exposure to O3, a time-course consistent with inflammation.

Original languageEnglish (US)
Pages (from-to)988-996
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume152
Issue number3
Publication statusPublished - Sep 1995

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ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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