TY - JOUR
T1 - Evidence for multiple micronutrient effects based on randomized controlled trials and meta-analyses in developing countries
AU - Christian, Parul
AU - Tielsch, James M.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Providing multiple micronutrients via supplements, powders, or fortified ready-to-use foods is increasingly becoming a strategy for simultaneously addressing multiple nutrient deficiencies in developing countries. The pros and cons of the "gold standard" randomized controlled trial (RCT) design and meta-analyses of trials for establishing efficacy of nutritional interventions are discussed. Over the past decade, numerous RCT have been undertaken to test the efficacy of multiple micronutrient supplementation in both pregnant women and young children. Outcomes of interest have ranged from birth weight to child growth, and infant morbidity and mortality to nutrient status and cognitive function. These RCT have also been submitted to meta-analyses for estimating pooled effect sizes for various outcomes. Meta-analyses of antenatal multiple micronutrient supplementation reveal amodest but significant increase in birthweight of 22.4 g (95%CI: 8.3, 36.4 g) and an 11% (95% CI: 3, 19) reduction in low birth weight but no impact on preterm birth or perinatal mortality. In children, small effect sizes of 0.13 (95% CI: 0.06, 0.21) for length/height and 0.14 (95% CI: 0.03, 0.25) for weight have been shown with 3 or more micronutrients compared to fewer micronutrients, but there is limited evidence for an impact on outcomes such as morbidity and cognitive function. Gaps in research and future challenges for programmatic application of this strategy for both pregnant women and young children are discussed.
AB - Providing multiple micronutrients via supplements, powders, or fortified ready-to-use foods is increasingly becoming a strategy for simultaneously addressing multiple nutrient deficiencies in developing countries. The pros and cons of the "gold standard" randomized controlled trial (RCT) design and meta-analyses of trials for establishing efficacy of nutritional interventions are discussed. Over the past decade, numerous RCT have been undertaken to test the efficacy of multiple micronutrient supplementation in both pregnant women and young children. Outcomes of interest have ranged from birth weight to child growth, and infant morbidity and mortality to nutrient status and cognitive function. These RCT have also been submitted to meta-analyses for estimating pooled effect sizes for various outcomes. Meta-analyses of antenatal multiple micronutrient supplementation reveal amodest but significant increase in birthweight of 22.4 g (95%CI: 8.3, 36.4 g) and an 11% (95% CI: 3, 19) reduction in low birth weight but no impact on preterm birth or perinatal mortality. In children, small effect sizes of 0.13 (95% CI: 0.06, 0.21) for length/height and 0.14 (95% CI: 0.03, 0.25) for weight have been shown with 3 or more micronutrients compared to fewer micronutrients, but there is limited evidence for an impact on outcomes such as morbidity and cognitive function. Gaps in research and future challenges for programmatic application of this strategy for both pregnant women and young children are discussed.
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U2 - 10.3945/jn.111.149898
DO - 10.3945/jn.111.149898
M3 - Article
C2 - 22157540
AN - SCOPUS:84855553990
SN - 0022-3166
VL - 142
SP - 173S-177S
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 1
ER -