Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study

Renate Nickel, Ulrich Wahn, Nobuyuki Hizawa, Nancy Maestri, David L. Duffy, Kathleen C. Barnes, Kirsten Beyer, Johannes Forster, Renate Bergmann, Fred Zepp, Volker Wahn, David G. Marsh

Research output: Contribution to journalArticlepeer-review

Abstract

Linkage of asthma and high total serum IgE levels to chromosome 12q15- q24.1 has been recently described. To evaluate this region further in regard to total IgE responsiveness, we genotyped 52 unrelated German children with persistently 'high' total serum IgE (selected from a noninterventional prospective multicenter cohort study) and their parents. We carefully defined a most extreme IgE phenotype and analyzed it as a dichotomous trait. We tested for lineage between high total IgE concentrations and nine polymorphic microsatellite markers on chromosome 12q15-q24.1 using the transmission/disequilibrium test. Evidence for lineage and allelic association for high total IgE was observed for four markers in this region. This study demonstrates the value of using extreme phenotypes in genetic analysis of a complex quantitative trait.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalGenomics
Volume46
Issue number1
DOIs
StatePublished - Nov 15 1997

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study'. Together they form a unique fingerprint.

Cite this