TY - JOUR
T1 - Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow
AU - Ceccatelli, S.
AU - Lundberg, J. M.
AU - Fahrenkrug, J.
AU - Bredt, D. S.
AU - Snyder, S. H.
AU - Hökfelt, T.
N1 - Funding Information:
Acknowledgements--This study was supported by the Swedish MRC (04X-2887, 14X-6554), the NIMH (MH43230) and Marianne och Marcus Wallenbergs Stiftelse. We thank Prof. J. Massouli6 for generous supply of AChE antiserum, and Ms W. Hiort and Ms K /~man for skilful technical assistance.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1992/12
Y1 - 1992/12
N2 - Vasoactive intestinal polypeptide and peptide histidine isoleucine, two peptides with a common precursor and with strong vasodilatory actions,14,16,22 have been suggested to be involved in control of blood flow through the hypothalamic portal blood vessels, 4 in this way regulating the amounts of releasing and inhibitory factors reaching the anterior pituitary. Using the indirect immunofluorescence technique, we now show that this system also contains the enzyme nitric oxide synthase, as well as acetylcholinesterase. It is therefore likely that the control of blood flow through the portal vessels is mediated via relaxation of smooth muscle cells with a high myogenic tone by neuronal release of four vasodilatory compounds, acetylcholine, vasoactive intestinal polypeptide, peptidine histidine isoleucine, and nitric oxide, i.e. a classic neurotransmitter, two neuropeptides and a gas.
AB - Vasoactive intestinal polypeptide and peptide histidine isoleucine, two peptides with a common precursor and with strong vasodilatory actions,14,16,22 have been suggested to be involved in control of blood flow through the hypothalamic portal blood vessels, 4 in this way regulating the amounts of releasing and inhibitory factors reaching the anterior pituitary. Using the indirect immunofluorescence technique, we now show that this system also contains the enzyme nitric oxide synthase, as well as acetylcholinesterase. It is therefore likely that the control of blood flow through the portal vessels is mediated via relaxation of smooth muscle cells with a high myogenic tone by neuronal release of four vasodilatory compounds, acetylcholine, vasoactive intestinal polypeptide, peptidine histidine isoleucine, and nitric oxide, i.e. a classic neurotransmitter, two neuropeptides and a gas.
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U2 - 10.1016/0306-4522(92)90518-7
DO - 10.1016/0306-4522(92)90518-7
M3 - Article
C2 - 1488122
AN - SCOPUS:0026485752
SN - 0306-4522
VL - 51
SP - 769
EP - 772
JO - Neuroscience
JF - Neuroscience
IS - 4
ER -