Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow

S. Ceccatelli, J. M. Lundberg, J. Fahrenkrug, D. S. Bredt, Solomon H Snyder, T. Hökfelt

Research output: Contribution to journalArticle

Abstract

Vasoactive intestinal polypeptide and peptide histidine isoleucine, two peptides with a common precursor and with strong vasodilatory actions,14,16,22 have been suggested to be involved in control of blood flow through the hypothalamic portal blood vessels, 4 in this way regulating the amounts of releasing and inhibitory factors reaching the anterior pituitary. Using the indirect immunofluorescence technique, we now show that this system also contains the enzyme nitric oxide synthase, as well as acetylcholinesterase. It is therefore likely that the control of blood flow through the portal vessels is mediated via relaxation of smooth muscle cells with a high myogenic tone by neuronal release of four vasodilatory compounds, acetylcholine, vasoactive intestinal polypeptide, peptidine histidine isoleucine, and nitric oxide, i.e. a classic neurotransmitter, two neuropeptides and a gas.

Original languageEnglish (US)
Pages (from-to)769-772
Number of pages4
JournalNeuroscience
Volume51
Issue number4
DOIs
StatePublished - 1992

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Vasoactive Intestinal Peptide
Nitric Oxide
Peptide PHI
Isoleucine
Acetylcholinesterase
Indirect Fluorescent Antibody Technique
Neuropeptides
Histidine
Nitric Oxide Synthase
Acetylcholine
Smooth Muscle Myocytes
Neurotransmitter Agents
Blood Vessels
Gases
Peptides
Enzymes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow. / Ceccatelli, S.; Lundberg, J. M.; Fahrenkrug, J.; Bredt, D. S.; Snyder, Solomon H; Hökfelt, T.

In: Neuroscience, Vol. 51, No. 4, 1992, p. 769-772.

Research output: Contribution to journalArticle

Ceccatelli, S, Lundberg, JM, Fahrenkrug, J, Bredt, DS, Snyder, SH & Hökfelt, T 1992, 'Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow', Neuroscience, vol. 51, no. 4, pp. 769-772. https://doi.org/10.1016/0306-4522(92)90518-7
Ceccatelli, S. ; Lundberg, J. M. ; Fahrenkrug, J. ; Bredt, D. S. ; Snyder, Solomon H ; Hökfelt, T. / Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow. In: Neuroscience. 1992 ; Vol. 51, No. 4. pp. 769-772.
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AU - Snyder, Solomon H

AU - Hökfelt, T.

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