Evidence for individual human peripheral blood lymphocytes bearing both B and T cell markers

H. B. Dickler, N Franklin Adkinson, W. D. Terry

Research output: Contribution to journalArticle

Abstract

LYMPHOCYTES are composed of two main populations: thymus-derived (T) lymphocytes which are largely responsible for cell-mediated immunity, and bursal-equivalent or bone-marrow derived (B) lymphocytes which are primarily involved in humoral immunity. B cells can be identified by the presence of fluorescence-detectable surface immunoglobulin1-3 and by their ability to bind antigen-antibody complexes or heat-aggregated immunoglobulin through the Fc portion of the immunoglobulin molecule4-7. Human T cells can be identified by their ability to form non-immune rosettes (E rosettes) with sheep red blood cells (SRBC)8-12. We report here that when these B and T cell markers were evaluated simultaneously oh individual cells, a small subpopulation reproducibly bore both markers. Further experiments seemed to rule out artefact as an explanation.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalNature
Volume247
Issue number5438
DOIs
StatePublished - 1974

Fingerprint

B-Lymphocytes
Lymphocytes
T-Lymphocytes
Immunoglobulin Fc Fragments
Humoral Immunity
Antigen-Antibody Complex
Cellular Immunity
Artifacts
Thymus Gland
Immunoglobulins
Sheep
Hot Temperature
Erythrocytes
Fluorescence
Bone Marrow
Population

ASJC Scopus subject areas

  • General

Cite this

Evidence for individual human peripheral blood lymphocytes bearing both B and T cell markers. / Dickler, H. B.; Adkinson, N Franklin; Terry, W. D.

In: Nature, Vol. 247, No. 5438, 1974, p. 213-215.

Research output: Contribution to journalArticle

@article{b12b25aeab424de6bb312bee10e1b706,
title = "Evidence for individual human peripheral blood lymphocytes bearing both B and T cell markers",
abstract = "LYMPHOCYTES are composed of two main populations: thymus-derived (T) lymphocytes which are largely responsible for cell-mediated immunity, and bursal-equivalent or bone-marrow derived (B) lymphocytes which are primarily involved in humoral immunity. B cells can be identified by the presence of fluorescence-detectable surface immunoglobulin1-3 and by their ability to bind antigen-antibody complexes or heat-aggregated immunoglobulin through the Fc portion of the immunoglobulin molecule4-7. Human T cells can be identified by their ability to form non-immune rosettes (E rosettes) with sheep red blood cells (SRBC)8-12. We report here that when these B and T cell markers were evaluated simultaneously oh individual cells, a small subpopulation reproducibly bore both markers. Further experiments seemed to rule out artefact as an explanation.",
author = "Dickler, {H. B.} and Adkinson, {N Franklin} and Terry, {W. D.}",
year = "1974",
doi = "10.1038/247213a0",
language = "English (US)",
volume = "247",
pages = "213--215",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5438",

}

TY - JOUR

T1 - Evidence for individual human peripheral blood lymphocytes bearing both B and T cell markers

AU - Dickler, H. B.

AU - Adkinson, N Franklin

AU - Terry, W. D.

PY - 1974

Y1 - 1974

N2 - LYMPHOCYTES are composed of two main populations: thymus-derived (T) lymphocytes which are largely responsible for cell-mediated immunity, and bursal-equivalent or bone-marrow derived (B) lymphocytes which are primarily involved in humoral immunity. B cells can be identified by the presence of fluorescence-detectable surface immunoglobulin1-3 and by their ability to bind antigen-antibody complexes or heat-aggregated immunoglobulin through the Fc portion of the immunoglobulin molecule4-7. Human T cells can be identified by their ability to form non-immune rosettes (E rosettes) with sheep red blood cells (SRBC)8-12. We report here that when these B and T cell markers were evaluated simultaneously oh individual cells, a small subpopulation reproducibly bore both markers. Further experiments seemed to rule out artefact as an explanation.

AB - LYMPHOCYTES are composed of two main populations: thymus-derived (T) lymphocytes which are largely responsible for cell-mediated immunity, and bursal-equivalent or bone-marrow derived (B) lymphocytes which are primarily involved in humoral immunity. B cells can be identified by the presence of fluorescence-detectable surface immunoglobulin1-3 and by their ability to bind antigen-antibody complexes or heat-aggregated immunoglobulin through the Fc portion of the immunoglobulin molecule4-7. Human T cells can be identified by their ability to form non-immune rosettes (E rosettes) with sheep red blood cells (SRBC)8-12. We report here that when these B and T cell markers were evaluated simultaneously oh individual cells, a small subpopulation reproducibly bore both markers. Further experiments seemed to rule out artefact as an explanation.

UR - http://www.scopus.com/inward/record.url?scp=0015968980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015968980&partnerID=8YFLogxK

U2 - 10.1038/247213a0

DO - 10.1038/247213a0

M3 - Article

C2 - 4589574

AN - SCOPUS:0015968980

VL - 247

SP - 213

EP - 215

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5438

ER -