Evidence for increased cardiovascular events in the fathers but not mothers of women with polycystic ovary syndrome

Mary C. Taylor, Anuradha Kar, Allen R. Kunselman, Christy M. Stetter, Andrea Dunaif, Richard S. Legro

Research output: Contribution to journalArticle

Abstract

Background: Polycystic ovary syndrome (PCOS) is a familial syndrome, associated with multiple cardiovascular disease (CVD) risk factors. Thus, parents of affected women may have a higher prevalence of CVD events than the general population. Methods: PCOS probands (n 410) and their participating parents (n 180 fathers and 211 mothers) were queried for CVD events in themselves and non-participating family members. In order to include the family CVD history of all parents, agreement between the proband and parental reports of CVD events was assessed. Estimated 10-year coronary heart disease (CHD) risk was calculated using the Framingham risk calculator. The National Health and Nutrition Examination Survey (NHANES) 20012002 database was used to generate gender, age and body mass index-relevant population parameters of CVD prevalence in the USA population. Results: Ninety-eight percent of the parents self-reporting of CVD events agreed with the probands report of parental heart attack history [Kappa 0.82; 95 CI: (0.69, 0.94)] and 99 with parental stroke history [Kappa=0.79; 95 CI: (0.62, 0.97)]. Fathers of women with PCOS had a higher prevalence of heart attack and stroke compared with the reference NHANES population (heart attack: 11.1 versus 5.3, P <0.0001; stroke: 3.0 versus 1.0, P 0.002). Fathers of women with PCOS had an elevated 10-year risk for CHD (11.5 versus 9.9 in NHANES, P=0.03). No statistically significant increased prevalence of CVD events or 10-year risk was noted in probands or mothers. Conclusions: Fathers, and not mothers, may be disproportionately burdened with CVD in PCOS families. The strengths of this study include the size of our cohort, the consistent phenotyping and the validation of probands reporting of parental CVD events.

Original languageEnglish (US)
Pages (from-to)2226-2231
Number of pages6
JournalHuman Reproduction
Volume26
Issue number8
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Polycystic Ovary Syndrome
Fathers
Cardiovascular Diseases
Mothers
Nutrition Surveys
Parents
Stroke
Myocardial Infarction
Population
Coronary Disease
Body Mass Index
Databases

Keywords

  • androgens
  • dyslipidemia
  • hypertension
  • insulin resistance
  • stroke

ASJC Scopus subject areas

  • Rehabilitation
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Taylor, M. C., Kar, A., Kunselman, A. R., Stetter, C. M., Dunaif, A., & Legro, R. S. (2011). Evidence for increased cardiovascular events in the fathers but not mothers of women with polycystic ovary syndrome. Human Reproduction, 26(8), 2226-2231. https://doi.org/10.1093/humrep/der101

Evidence for increased cardiovascular events in the fathers but not mothers of women with polycystic ovary syndrome. / Taylor, Mary C.; Kar, Anuradha; Kunselman, Allen R.; Stetter, Christy M.; Dunaif, Andrea; Legro, Richard S.

In: Human Reproduction, Vol. 26, No. 8, 08.2011, p. 2226-2231.

Research output: Contribution to journalArticle

Taylor, Mary C. ; Kar, Anuradha ; Kunselman, Allen R. ; Stetter, Christy M. ; Dunaif, Andrea ; Legro, Richard S. / Evidence for increased cardiovascular events in the fathers but not mothers of women with polycystic ovary syndrome. In: Human Reproduction. 2011 ; Vol. 26, No. 8. pp. 2226-2231.
@article{5c62c4baf565406e9654a3bc3f37aaba,
title = "Evidence for increased cardiovascular events in the fathers but not mothers of women with polycystic ovary syndrome",
abstract = "Background: Polycystic ovary syndrome (PCOS) is a familial syndrome, associated with multiple cardiovascular disease (CVD) risk factors. Thus, parents of affected women may have a higher prevalence of CVD events than the general population. Methods: PCOS probands (n 410) and their participating parents (n 180 fathers and 211 mothers) were queried for CVD events in themselves and non-participating family members. In order to include the family CVD history of all parents, agreement between the proband and parental reports of CVD events was assessed. Estimated 10-year coronary heart disease (CHD) risk was calculated using the Framingham risk calculator. The National Health and Nutrition Examination Survey (NHANES) 20012002 database was used to generate gender, age and body mass index-relevant population parameters of CVD prevalence in the USA population. Results: Ninety-eight percent of the parents self-reporting of CVD events agreed with the probands report of parental heart attack history [Kappa 0.82; 95 CI: (0.69, 0.94)] and 99 with parental stroke history [Kappa=0.79; 95 CI: (0.62, 0.97)]. Fathers of women with PCOS had a higher prevalence of heart attack and stroke compared with the reference NHANES population (heart attack: 11.1 versus 5.3, P <0.0001; stroke: 3.0 versus 1.0, P 0.002). Fathers of women with PCOS had an elevated 10-year risk for CHD (11.5 versus 9.9 in NHANES, P=0.03). No statistically significant increased prevalence of CVD events or 10-year risk was noted in probands or mothers. Conclusions: Fathers, and not mothers, may be disproportionately burdened with CVD in PCOS families. The strengths of this study include the size of our cohort, the consistent phenotyping and the validation of probands reporting of parental CVD events.",
keywords = "androgens, dyslipidemia, hypertension, insulin resistance, stroke",
author = "Taylor, {Mary C.} and Anuradha Kar and Kunselman, {Allen R.} and Stetter, {Christy M.} and Andrea Dunaif and Legro, {Richard S.}",
year = "2011",
month = "8",
doi = "10.1093/humrep/der101",
language = "English (US)",
volume = "26",
pages = "2226--2231",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Evidence for increased cardiovascular events in the fathers but not mothers of women with polycystic ovary syndrome

AU - Taylor, Mary C.

AU - Kar, Anuradha

AU - Kunselman, Allen R.

AU - Stetter, Christy M.

AU - Dunaif, Andrea

AU - Legro, Richard S.

PY - 2011/8

Y1 - 2011/8

N2 - Background: Polycystic ovary syndrome (PCOS) is a familial syndrome, associated with multiple cardiovascular disease (CVD) risk factors. Thus, parents of affected women may have a higher prevalence of CVD events than the general population. Methods: PCOS probands (n 410) and their participating parents (n 180 fathers and 211 mothers) were queried for CVD events in themselves and non-participating family members. In order to include the family CVD history of all parents, agreement between the proband and parental reports of CVD events was assessed. Estimated 10-year coronary heart disease (CHD) risk was calculated using the Framingham risk calculator. The National Health and Nutrition Examination Survey (NHANES) 20012002 database was used to generate gender, age and body mass index-relevant population parameters of CVD prevalence in the USA population. Results: Ninety-eight percent of the parents self-reporting of CVD events agreed with the probands report of parental heart attack history [Kappa 0.82; 95 CI: (0.69, 0.94)] and 99 with parental stroke history [Kappa=0.79; 95 CI: (0.62, 0.97)]. Fathers of women with PCOS had a higher prevalence of heart attack and stroke compared with the reference NHANES population (heart attack: 11.1 versus 5.3, P <0.0001; stroke: 3.0 versus 1.0, P 0.002). Fathers of women with PCOS had an elevated 10-year risk for CHD (11.5 versus 9.9 in NHANES, P=0.03). No statistically significant increased prevalence of CVD events or 10-year risk was noted in probands or mothers. Conclusions: Fathers, and not mothers, may be disproportionately burdened with CVD in PCOS families. The strengths of this study include the size of our cohort, the consistent phenotyping and the validation of probands reporting of parental CVD events.

AB - Background: Polycystic ovary syndrome (PCOS) is a familial syndrome, associated with multiple cardiovascular disease (CVD) risk factors. Thus, parents of affected women may have a higher prevalence of CVD events than the general population. Methods: PCOS probands (n 410) and their participating parents (n 180 fathers and 211 mothers) were queried for CVD events in themselves and non-participating family members. In order to include the family CVD history of all parents, agreement between the proband and parental reports of CVD events was assessed. Estimated 10-year coronary heart disease (CHD) risk was calculated using the Framingham risk calculator. The National Health and Nutrition Examination Survey (NHANES) 20012002 database was used to generate gender, age and body mass index-relevant population parameters of CVD prevalence in the USA population. Results: Ninety-eight percent of the parents self-reporting of CVD events agreed with the probands report of parental heart attack history [Kappa 0.82; 95 CI: (0.69, 0.94)] and 99 with parental stroke history [Kappa=0.79; 95 CI: (0.62, 0.97)]. Fathers of women with PCOS had a higher prevalence of heart attack and stroke compared with the reference NHANES population (heart attack: 11.1 versus 5.3, P <0.0001; stroke: 3.0 versus 1.0, P 0.002). Fathers of women with PCOS had an elevated 10-year risk for CHD (11.5 versus 9.9 in NHANES, P=0.03). No statistically significant increased prevalence of CVD events or 10-year risk was noted in probands or mothers. Conclusions: Fathers, and not mothers, may be disproportionately burdened with CVD in PCOS families. The strengths of this study include the size of our cohort, the consistent phenotyping and the validation of probands reporting of parental CVD events.

KW - androgens

KW - dyslipidemia

KW - hypertension

KW - insulin resistance

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=79960533337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960533337&partnerID=8YFLogxK

U2 - 10.1093/humrep/der101

DO - 10.1093/humrep/der101

M3 - Article

VL - 26

SP - 2226

EP - 2231

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 8

ER -