Evidence for genetic linkage Alzheimer's disease to chromosome 10q

L. Bertram, D. Blacker, K. Mullin, D. Keeney, J. Jones, S. Basu, S. Yhu, M. G. McInnis, R. C.P. Go, K. Vekrellis, D. J. Selkoe, A. J. Saunders, R. E. Tanzi

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Aβ, the principal component of β-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene.

    Original languageEnglish (US)
    Pages (from-to)2302-2303
    Number of pages2
    JournalScience
    Volume290
    Issue number5500
    DOIs
    StatePublished - Dec 22 2000

    ASJC Scopus subject areas

    • General

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