Evidence for genetic linkage Alzheimer's disease to chromosome 10q

L. Bertram, D. Blacker, K. Mullin, D. Keeney, J. Jones, S. Basu, S. Yhu, M. G. McInnis, R. C P Go, K. Vekrellis, D. J. Selkoe, A. J. Saunders, R. E. Tanzi

Research output: Contribution to journalArticle

Abstract

Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Aβ, the principal component of β-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene.

Original languageEnglish (US)
Pages (from-to)2302-2303
Number of pages2
JournalScience
Volume290
Issue number5500
DOIs
StatePublished - Dec 22 2000
Externally publishedYes

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Insulysin
Genetic Linkage
Alzheimer Disease
Chromosomes
Microglia
Genetic Markers
Amyloid
Genes
Alleles
Neurons

ASJC Scopus subject areas

  • General

Cite this

Bertram, L., Blacker, D., Mullin, K., Keeney, D., Jones, J., Basu, S., ... Tanzi, R. E. (2000). Evidence for genetic linkage Alzheimer's disease to chromosome 10q. Science, 290(5500), 2302-2303. https://doi.org/10.1126/science.290.5500.2302

Evidence for genetic linkage Alzheimer's disease to chromosome 10q. / Bertram, L.; Blacker, D.; Mullin, K.; Keeney, D.; Jones, J.; Basu, S.; Yhu, S.; McInnis, M. G.; Go, R. C P; Vekrellis, K.; Selkoe, D. J.; Saunders, A. J.; Tanzi, R. E.

In: Science, Vol. 290, No. 5500, 22.12.2000, p. 2302-2303.

Research output: Contribution to journalArticle

Bertram, L, Blacker, D, Mullin, K, Keeney, D, Jones, J, Basu, S, Yhu, S, McInnis, MG, Go, RCP, Vekrellis, K, Selkoe, DJ, Saunders, AJ & Tanzi, RE 2000, 'Evidence for genetic linkage Alzheimer's disease to chromosome 10q', Science, vol. 290, no. 5500, pp. 2302-2303. https://doi.org/10.1126/science.290.5500.2302
Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S et al. Evidence for genetic linkage Alzheimer's disease to chromosome 10q. Science. 2000 Dec 22;290(5500):2302-2303. https://doi.org/10.1126/science.290.5500.2302
Bertram, L. ; Blacker, D. ; Mullin, K. ; Keeney, D. ; Jones, J. ; Basu, S. ; Yhu, S. ; McInnis, M. G. ; Go, R. C P ; Vekrellis, K. ; Selkoe, D. J. ; Saunders, A. J. ; Tanzi, R. E. / Evidence for genetic linkage Alzheimer's disease to chromosome 10q. In: Science. 2000 ; Vol. 290, No. 5500. pp. 2302-2303.
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AU - Yhu, S.

AU - McInnis, M. G.

AU - Go, R. C P

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