Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstriction prostaglandins in the airways of subjects with mild asthma

M. C. Liu, E. R. Bleecker, L. M. Lichtenstein, A. Kagey-Sobotka, Y. Niv, T. L. McLemore, S. Permutt, D. Proud, W. C. Hubbard

Research output: Contribution to journalArticlepeer-review

Abstract

Histamine and certain cyclooxygenase products of arachidonic acid have been implicated as mediators of inflammation and are potent constrictors of human airways. Because asthma may represent manifestations of chronic inflammation of the airways, the levels of histamine and six prostanoid mediators were measured in airway fluids obtained by bronchoalveolar lavage (BAL) of 12 normal, 11 allergic rhinitic, and 15 asymptomatic, allergic asthmatic subjects. Simultaneous profiling of prostanoid mediators in individual samples was performed using gas chromatography-mass spectrometry. Levels of PGD2, 9α,11β-PGF2 and PGF(2α) were 12 to 22 times higher in asthmatic than in normal subjects (p<0.01), with concentrations in airway fluids of asthmatic subjects after correction for dilution of 3.8, 0.5, and 1.4 nanomolar, respectively. Levels of PGD2 and 9α,11β-PGF2 were increased nearly tenfold in asthmatic subjects compared with those in rhinitic subjects (p<0.01), distinguishing the subjects with lower airway disease from those with another atopic condition. Histamine levels were increased fourfold in asthmatic subjects compared with those in normal subjects (p<0.001); however, similar increases were found in rhinitic subjects. We conclude that elevated levels of multiple mediators with potent bronchoconstricting activity are present in the airways of subjects with mild asthma, indicating that even mild disease is associated with evidence of airway inflammatory. The interactions of bronchoconstricting mediators and airway inflammation may play important roles in the pathogenesis of asthma.

Original languageEnglish (US)
Pages (from-to)126-132
Number of pages7
JournalAmerican Review of Respiratory Disease
Volume142
Issue number1
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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