Evidence for dopamine D-2 receptors on cholinergic interneurons in the rat caudate-putamen

Valina L. Dawson, Ted M. Dawson, Francis M. Filloux, James K. Wamsley

Research output: Contribution to journalArticle

Abstract

The aziridinium ion of ethylcholine (AF64A) is a neurotoxin that has demonstrated selectivity for cholinergic neurons. Unilateral stereotaxic injection of AF64A into the caudate-putamen of rats, resulted in a decrease in dopamine D-2 receptors as evidenced by a decrease in [3H]-sulpiride binding. Dopamine D-1 receptors, labeled with [3H]-SCH 23390, were unchanged. The efficacy of the lesion was demonstrated by the reduction of Na+-dependent high affinity choline uptake sites labeled with [3H]-hemicholinium-3. These data indicate that a population of D-2 receptors are postsynaptic on cholinergic interneurons within the striatum of rat brain.

Original languageEnglish (US)
Pages (from-to)1933-1939
Number of pages7
JournalLife Sciences
Volume42
Issue number20
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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