Evidence for conversion of 5-fluorocytosine to 5-fluorouracil in humans: possible factor in 5-fluorocytosine clinical toxicity

R. B. Diasio, D. E. Lakings, J. E. Bennett

Research output: Contribution to journalArticle

Abstract

A gas chromatographic-mass spectrometric method for detecting 5-fluorouracil (5-FU) in serum at concentrations as low as 10 ng/ml was used to determine to what extent 5-FU was present in the serum of patients taking oral 5-fluorocytosine (5-FC). Preliminary studies in two patients and two healthy volunteers given an initial 2-g oral dose of 5-FC demonstrated sustained serum 5-FU levels (>100 ng/ml during the 5 h after ingestion of drug. Pharmaceutical preparations of 5-FC used in these studies were shown to be insignificantly contaminated with 5-FU (

Original languageEnglish (US)
Pages (from-to)903-908
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume14
Issue number6
StatePublished - 1978
Externally publishedYes

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Flucytosine
Fluorouracil
Serum
Pharmaceutical Preparations
Healthy Volunteers
Eating
Gases

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Evidence for conversion of 5-fluorocytosine to 5-fluorouracil in humans : possible factor in 5-fluorocytosine clinical toxicity. / Diasio, R. B.; Lakings, D. E.; Bennett, J. E.

In: Antimicrobial Agents and Chemotherapy, Vol. 14, No. 6, 1978, p. 903-908.

Research output: Contribution to journalArticle

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