Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia

Robert M. Cohen, William E. Semple, Michael Gross, Thomas E. Nordahl, A. Catherine King, David Pickar, Robert M. Post

Research output: Contribution to journalArticle

Abstract

Regional glucose metabolic rates were measured in affectively disordered patients during the performance of auditory discrimination. Those regions previously observed as abnormal in schizophrenia were examined to see if similar alterations might be associated with affective disorder. The abnormalities observed in the mid-prefrontal cortex, an area that appears to be an important biologic determinant of the sustained attention required of subjects in this task, are similar to those previously observed in schizophrenia. Moreover, the abnormalities do not appear to relate directly to symptomatology or the subject's performance. The authors discuss the possibility that this abnormality may reflect dysfunction in the integrating component of the attention network critical for the maintenance of goal-directed behavior and thus represent a psychosis vulnerability factor in some patients.

Original languageEnglish (US)
Pages (from-to)241-254
Number of pages14
JournalNeuropsychopharmacology
Volume2
Issue number4
StatePublished - Dec 1989
Externally publishedYes

Fingerprint

Mood Disorders
Schizophrenia
Glucose
Prefrontal Cortex
Psychotic Disorders
Maintenance

Keywords

  • Affective disorders
  • Attention
  • Cerebral cortex-physiopathology
  • Frontal lobe-physiopathology
  • Schizophrenia
  • Tomgraphy-emission computed

ASJC Scopus subject areas

  • Pharmacology

Cite this

Cohen, R. M., Semple, W. E., Gross, M., Nordahl, T. E., King, A. C., Pickar, D., & Post, R. M. (1989). Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia. Neuropsychopharmacology, 2(4), 241-254.

Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia. / Cohen, Robert M.; Semple, William E.; Gross, Michael; Nordahl, Thomas E.; King, A. Catherine; Pickar, David; Post, Robert M.

In: Neuropsychopharmacology, Vol. 2, No. 4, 12.1989, p. 241-254.

Research output: Contribution to journalArticle

Cohen, RM, Semple, WE, Gross, M, Nordahl, TE, King, AC, Pickar, D & Post, RM 1989, 'Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia', Neuropsychopharmacology, vol. 2, no. 4, pp. 241-254.
Cohen RM, Semple WE, Gross M, Nordahl TE, King AC, Pickar D et al. Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia. Neuropsychopharmacology. 1989 Dec;2(4):241-254.
Cohen, Robert M. ; Semple, William E. ; Gross, Michael ; Nordahl, Thomas E. ; King, A. Catherine ; Pickar, David ; Post, Robert M. / Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia. In: Neuropsychopharmacology. 1989 ; Vol. 2, No. 4. pp. 241-254.
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