Evidence for cholinergic neurites in senile plaques

Cheryl A. Kitt, Donald L. Price, Robert G. Struble, Linda C. Cork, Bruce H. Wainer, Mark W. Becher, William C. Mobley

Research output: Contribution to journalArticlepeer-review

Abstract

In the neocortices and amygdalae of young and aged macaques, cholinergic axons were identified by means of a monoclonal antibody to bovine choline acetyltransferase. Many fine, linear, immunoreactive profiles were seen in these animals. In the older animals, some cholinergic axons showed multifocal enlargements along their course. In some instances, neurites with choline acetyltransferase immunoreactivity were associated with deposits of amyloid (visualized with thioflavin T fluorescence). The appearance of these amyloid-associated abnormal cholinergic processes was similar to that ofneurites in senile plaques, as shown by conventional silver impregnation techniques. Cholinergic systems thus give rise to some of the neurites within senile plaques.

Original languageEnglish (US)
Pages (from-to)1443-1445
Number of pages3
JournalScience
Volume226
Issue number4681
DOIs
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • General

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