Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China

Justin T Lessler, Steven Riley, Jonathan M. Read, Shuying Wang, Huachen Zhu, Gavin J D Smith, Yi Guan, Chao Qiang Jiang, Derek A T Cummings

Research output: Contribution to journalArticle

Abstract

A key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response. Although antibody titers measure that response, the interpretation of titers to multiple strains - from the same sera - in terms of infection history is clouded by age effects, cross reactivity and immune waning. From July to September 2009, we collected serum samples from 151 residents of Guangdong Province, China, 7 to 81 years of age. Neutralization tests were performed against strains representing six antigenic clusters of H3N2 influenza circulating between 1968 and 2008, and three recent locally circulating strains. Patterns of neutralization titers were compared based on age at time of testing and age at time of the first isolation of each virus. Neutralization titers were highest for H3N2 strains that circulated in an individual's first decade of life (peaking at 7 years). Further, across strains and ages at testing, statistical models strongly supported a pattern of titers declining smoothly with age at the time a strain was first isolated. Those born 10 or more years after a strain emerged generally had undetectable neutralization titers to that strain (

Original languageEnglish (US)
Article numbere1002802
Pages (from-to)26
Number of pages1
JournalPLoS Pathogens
Volume8
Issue number7
DOIs
StatePublished - Jul 2012

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Human Influenza
Antibody Formation
China
Neutralization Tests
Adaptive Immunity
Statistical Models
Serum
Observation
Viruses
Antibodies
Infection

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Cite this

Lessler, J. T., Riley, S., Read, J. M., Wang, S., Zhu, H., Smith, G. J. D., ... Cummings, D. A. T. (2012). Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China. PLoS Pathogens, 8(7), 26. [e1002802]. https://doi.org/10.1371/journal.ppat.1002802

Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China. / Lessler, Justin T; Riley, Steven; Read, Jonathan M.; Wang, Shuying; Zhu, Huachen; Smith, Gavin J D; Guan, Yi; Jiang, Chao Qiang; Cummings, Derek A T.

In: PLoS Pathogens, Vol. 8, No. 7, e1002802, 07.2012, p. 26.

Research output: Contribution to journalArticle

Lessler, JT, Riley, S, Read, JM, Wang, S, Zhu, H, Smith, GJD, Guan, Y, Jiang, CQ & Cummings, DAT 2012, 'Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China', PLoS Pathogens, vol. 8, no. 7, e1002802, pp. 26. https://doi.org/10.1371/journal.ppat.1002802
Lessler, Justin T ; Riley, Steven ; Read, Jonathan M. ; Wang, Shuying ; Zhu, Huachen ; Smith, Gavin J D ; Guan, Yi ; Jiang, Chao Qiang ; Cummings, Derek A T. / Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China. In: PLoS Pathogens. 2012 ; Vol. 8, No. 7. pp. 26.
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