Evidence for anomalous network connectivity during working memory encoding in Schizophrenia

An ICA based analysis

Shashwath A. Meda, Michael C. Stevens, Bradley S. Folley, Vince Daniel Calhoun, Godfrey D. Pearlson

Research output: Contribution to journalArticle

Abstract

Background: Numerous neuroimaging studies report abnormal regional brain activity during working memory performance in schizophrenia, but few have examined brain network integration as determined by "functional connectivity" analyses. Methodology/Principal Findings: We used independent component analysis (ICA) to identify and characterize dysfunctional spatiotemporal networks in schizophrenia engaged during the different stages (encoding and recognition) of a Sternberg working memory fMRI paradigm. 37 chronic schizophrenia and 54 healthy age/gender-matched participants performed a modified Sternberg Item Recognition fMRI task. Time series images preprocessed with SPM2 were analyzed using ICA. Schizophrenia patients showed relatively less engagement of several distinct "normal" encoding-related working memory networks compared to controls. These encoding networks comprised 1) left posterior parietal-left dorsal/ ventrolateral prefrontal cortex, cingulate, basal ganglia, 2) right posterior parietal, right dorsolateral prefrontal cortex and 3) default mode network. In addition, the left fronto-parietal network demonstrated a load-dependent functional response during encoding. Network engagement that differed between groups during recognition comprised the posterior cingulate, cuneus and hippocampus/parahippocampus. As expected, working memory task accuracy differed between groups (p

Original languageEnglish (US)
Article numbere7911
JournalPLoS One
Volume4
Issue number11
DOIs
StatePublished - Nov 19 2009

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Independent component analysis
Short-Term Memory
Schizophrenia
Data storage equipment
Prefrontal Cortex
Brain
Magnetic Resonance Imaging
Neuroimaging
brain
Occipital Lobe
Gyrus Cinguli
hippocampus
Basal Ganglia
Time series
time series analysis
Hippocampus
schizophrenia
gender
Recognition (Psychology)
prefrontal cortex

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Evidence for anomalous network connectivity during working memory encoding in Schizophrenia : An ICA based analysis. / Meda, Shashwath A.; Stevens, Michael C.; Folley, Bradley S.; Calhoun, Vince Daniel; Pearlson, Godfrey D.

In: PLoS One, Vol. 4, No. 11, e7911, 19.11.2009.

Research output: Contribution to journalArticle

Meda, Shashwath A. ; Stevens, Michael C. ; Folley, Bradley S. ; Calhoun, Vince Daniel ; Pearlson, Godfrey D. / Evidence for anomalous network connectivity during working memory encoding in Schizophrenia : An ICA based analysis. In: PLoS One. 2009 ; Vol. 4, No. 11.
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