Evidence for a role of the arachidonic acid cascade in affective disorders

A review

Elizabeth L. Sublette, Mark J. Russ, Gwenn Smith

Research output: Contribution to journalArticle

Abstract

The treatment of affective disorders continues to present significant clinical challenges, notwithstanding the existence of available mood stabilizers and antidepressants. These difficulties include incomplete response, relapse, and intolerable medication side effects. Fundamental to the therapeutic impasse is incomplete knowledge concerning the neurobiology of mood disorders. Although some relevant biochemical pathways have been identified, including abnormalities of monoamine neurotransmission and of immunological functioning, a fuller understanding is likely to embrace other interrelated pathways. Arachidonic acid (AA) and prostaglandins (PGs) are important second messengers in the central nervous system that participate in signal transduction, inflammation and other vital processes. Their release, turnover, and metabolism represent the 'arachidonic acid cascade'. A significant body of diverse clinical and preclinical research suggests that the AA cascade may be important in affective states. This paper reviews the literature describing the association of affective illness with AA and its metabolites. Possible links between this and other prevailing hypotheses are considered, and implications for further research and for treatment are discussed.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalBipolar Disorders
Volume6
Issue number2
DOIs
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Mood Disorders
Arachidonic Acid
Neurobiology
Second Messenger Systems
Research
Synaptic Transmission
Antidepressive Agents
Prostaglandins
Signal Transduction
Central Nervous System
Inflammation
Recurrence
Therapeutics

Keywords

  • Arachidonic acid
  • Bipolar disorders
  • Depression
  • Essential fatty acids
  • Mania
  • Mood disorders
  • Prostaglandins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Evidence for a role of the arachidonic acid cascade in affective disorders : A review. / Sublette, Elizabeth L.; Russ, Mark J.; Smith, Gwenn.

In: Bipolar Disorders, Vol. 6, No. 2, 04.2004, p. 95-105.

Research output: Contribution to journalArticle

Sublette, Elizabeth L. ; Russ, Mark J. ; Smith, Gwenn. / Evidence for a role of the arachidonic acid cascade in affective disorders : A review. In: Bipolar Disorders. 2004 ; Vol. 6, No. 2. pp. 95-105.
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