Evidence for a prostate cancer linkage to chromosome 20 in 159 hereditary prostate cancer families

S. L. Zheng, J. Xu, S. D. Isaacs, K. Wiley, B. I. Chang, E. R. Bleecker, Patrick Walsh, J. M. Trent, D. A. Meyers, William B Isaacs

Research output: Contribution to journalArticle

Abstract

Prostate cancer is the most common malignancy diagnosed in men in the US. Genetic susceptibility to prostate cancer has been well documented. A region at chromosome 20q13 (HPC20) has been reported to be linked to a prostate cancer susceptibility gene. To confirm this finding, we genotyped 16 markers spanning ∼95 cM on chromosome 20 in 159 hereditary prostate cancer (HPC) families. Positive (but not statistically significant) linkage scores were observed from 20pter to 20q11, with the highest non-parametric linkage (NPL) score for the complete dataset of 1.02 (P=0.15) being observed at D20S195 at 20q11. Evidence for linkage from parametric analyses with a dominant or a recessive model was weak. Interestingly, consistent with the original findings of linkage to 20 g higher linkage scores were observed in the subsets of families with a later age at diagnosis (≥65 years; n=80, NPL=1.94, P=0.029 at D20S186), fewer than five affected family members (n=69, NPL=1.74, P=0.037 at D20S889), or without male-to-male disease transmission (n=60, NPL=1.01, P=0.15 at D20S117). The region with positive linkage scores spanned ∼60 cM from 20pter to 20q11 in these subsets of families. Our results are consistent with a prostate cancer susceptibility locus on chromosome 20.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalHuman Genetics
Volume108
Issue number5
DOIs
StatePublished - 2001

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Chromosomes, Human, Pair 20
Prostatic Neoplasms
Neoplasm Genes
Genetic Predisposition to Disease
Chromosomes
Familial Prostate cancer
Neoplasms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Evidence for a prostate cancer linkage to chromosome 20 in 159 hereditary prostate cancer families. / Zheng, S. L.; Xu, J.; Isaacs, S. D.; Wiley, K.; Chang, B. I.; Bleecker, E. R.; Walsh, Patrick; Trent, J. M.; Meyers, D. A.; Isaacs, William B.

In: Human Genetics, Vol. 108, No. 5, 2001, p. 430-435.

Research output: Contribution to journalArticle

Zheng, SL, Xu, J, Isaacs, SD, Wiley, K, Chang, BI, Bleecker, ER, Walsh, P, Trent, JM, Meyers, DA & Isaacs, WB 2001, 'Evidence for a prostate cancer linkage to chromosome 20 in 159 hereditary prostate cancer families', Human Genetics, vol. 108, no. 5, pp. 430-435. https://doi.org/10.1007/s004390100513
Zheng, S. L. ; Xu, J. ; Isaacs, S. D. ; Wiley, K. ; Chang, B. I. ; Bleecker, E. R. ; Walsh, Patrick ; Trent, J. M. ; Meyers, D. A. ; Isaacs, William B. / Evidence for a prostate cancer linkage to chromosome 20 in 159 hereditary prostate cancer families. In: Human Genetics. 2001 ; Vol. 108, No. 5. pp. 430-435.
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