Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer

Bao Li Chang, Elizabeth M. Gillanders, Sarah D. Isaacs, Kathy E. Wiley, Tamara Adams, Aubrey R. Turner, S. Lilly Zheng, Deborah A. Meyers, John D. Carpten, Patrick C. Walsh, Jeffrey M. Trent, Jianfeng Xu, William B. Isaacs

Research output: Contribution to journalArticlepeer-review

Abstract

To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalCancer Letters
Volume219
Issue number2
DOIs
StatePublished - Mar 10 2005

Keywords

  • Cancer
  • Genome-wide scan
  • Hereditary
  • Linkage
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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