Evidence for a flow-independent contribution to the phenomenon of thallium redistribution

Joseph L. Gerry; Lewis C. Becker; John T. Flaherty; Myron L. Weisfeldt

doi:10.1016/0002-9149(80)90220-9

Evidence for a flow-independent contribution to the phenomenon of thallium redistribution

Joseph L. Gerry, Lewis C. Becker, John T. Flaherty, Myron L. Weisfeldt

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Although thallium-201 is known to redistribute slowly into regions of ischemic myocardium after restoration of blood flow, it is not clear to what extent normalization of flow is an essential requirement for the redistribution process. In a search for a flow-independent component of thallium redistribution, 12 dogs with stenosis of the circumflex coronary artery underwent atrial pacing for either 20 minutes (group I, 6 dogs) or 2 hours (group II, 6 dogs). Radioactive thallium and radioactive microspheres, 7 to 10 μ, were injected after 10 minutes of atrial pacing in both groups. Pacing resulted in a 40 percent reduction in subendocardial blood flow to the circumflex-perfused myocardium in both groups I and II. This relative reduction in flow was maintained at a stable level over the 2 hour pacing period in group II. Thallium activity in the relatively ischemic zone was significantly greater in dogs with 2 hours of pacing (group II) than in those with 10 minutes of pacing (group I). Redistribution of thallium occurred despite the continued presence of reduced flow in circumflex-perfused endocardial tissue. These data suggest that a significant component of thallium redistribution may be flow-independent.

Original language	English (US)
Pages (from-to)	58-62
Number of pages	5
Journal	The American journal of cardiology
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/0002-9149(80)90220-9
State	Published - Jan 1980

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0002-9149(80)90220-9

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title = "Evidence for a flow-independent contribution to the phenomenon of thallium redistribution",

abstract = "Although thallium-201 is known to redistribute slowly into regions of ischemic myocardium after restoration of blood flow, it is not clear to what extent normalization of flow is an essential requirement for the redistribution process. In a search for a flow-independent component of thallium redistribution, 12 dogs with stenosis of the circumflex coronary artery underwent atrial pacing for either 20 minutes (group I, 6 dogs) or 2 hours (group II, 6 dogs). Radioactive thallium and radioactive microspheres, 7 to 10 μ, were injected after 10 minutes of atrial pacing in both groups. Pacing resulted in a 40 percent reduction in subendocardial blood flow to the circumflex-perfused myocardium in both groups I and II. This relative reduction in flow was maintained at a stable level over the 2 hour pacing period in group II. Thallium activity in the relatively ischemic zone was significantly greater in dogs with 2 hours of pacing (group II) than in those with 10 minutes of pacing (group I). Redistribution of thallium occurred despite the continued presence of reduced flow in circumflex-perfused endocardial tissue. These data suggest that a significant component of thallium redistribution may be flow-independent.",

author = "Gerry, {Joseph L.} and Becker, {Lewis C.} and Flaherty, {John T.} and Weisfeldt, {Myron L.}",

note = "Funding Information: From the Department of Medicine, The Johns Hopkins Medical Institutions and Hospital, Baltimore, Maryland. This study was supported by the Soecialized Center of Research for lschemic Heart Disease, Contract P-50-HL-17655-62 from the National Institutes of Health, Bethesda, Maryland. Dr. Flaherty is a recipient of Research Career Development Award 5 K04 HL 00019 from the National Institutes of Health. Manuscript received May 16, 1979; revised manuscript received July 31, 1979, accepted August 3, 1979.",

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N1 - Funding Information: From the Department of Medicine, The Johns Hopkins Medical Institutions and Hospital, Baltimore, Maryland. This study was supported by the Soecialized Center of Research for lschemic Heart Disease, Contract P-50-HL-17655-62 from the National Institutes of Health, Bethesda, Maryland. Dr. Flaherty is a recipient of Research Career Development Award 5 K04 HL 00019 from the National Institutes of Health. Manuscript received May 16, 1979; revised manuscript received July 31, 1979, accepted August 3, 1979.

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N2 - Although thallium-201 is known to redistribute slowly into regions of ischemic myocardium after restoration of blood flow, it is not clear to what extent normalization of flow is an essential requirement for the redistribution process. In a search for a flow-independent component of thallium redistribution, 12 dogs with stenosis of the circumflex coronary artery underwent atrial pacing for either 20 minutes (group I, 6 dogs) or 2 hours (group II, 6 dogs). Radioactive thallium and radioactive microspheres, 7 to 10 μ, were injected after 10 minutes of atrial pacing in both groups. Pacing resulted in a 40 percent reduction in subendocardial blood flow to the circumflex-perfused myocardium in both groups I and II. This relative reduction in flow was maintained at a stable level over the 2 hour pacing period in group II. Thallium activity in the relatively ischemic zone was significantly greater in dogs with 2 hours of pacing (group II) than in those with 10 minutes of pacing (group I). Redistribution of thallium occurred despite the continued presence of reduced flow in circumflex-perfused endocardial tissue. These data suggest that a significant component of thallium redistribution may be flow-independent.

AB - Although thallium-201 is known to redistribute slowly into regions of ischemic myocardium after restoration of blood flow, it is not clear to what extent normalization of flow is an essential requirement for the redistribution process. In a search for a flow-independent component of thallium redistribution, 12 dogs with stenosis of the circumflex coronary artery underwent atrial pacing for either 20 minutes (group I, 6 dogs) or 2 hours (group II, 6 dogs). Radioactive thallium and radioactive microspheres, 7 to 10 μ, were injected after 10 minutes of atrial pacing in both groups. Pacing resulted in a 40 percent reduction in subendocardial blood flow to the circumflex-perfused myocardium in both groups I and II. This relative reduction in flow was maintained at a stable level over the 2 hour pacing period in group II. Thallium activity in the relatively ischemic zone was significantly greater in dogs with 2 hours of pacing (group II) than in those with 10 minutes of pacing (group I). Redistribution of thallium occurred despite the continued presence of reduced flow in circumflex-perfused endocardial tissue. These data suggest that a significant component of thallium redistribution may be flow-independent.

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Evidence for a flow-independent contribution to the phenomenon of thallium redistribution

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