Evidence-based toxicology for the 21st century: Opportunities and challenges

Martin L. Stephens, Melvin Andersen, Richard A. Becker, Kellyn Betts, Kim Boekelheide, Ed Carney, Robert Chapin, Dennis Devlin, Suzanne Fitzpatrick, John R. Fowle, Patricia Harlow, Thomas Hartung, Sebastian Hoffmann, Michael Holsapple, Abigail Jacobs, Richard Judson, Olga Naidenko, Tim Pastoor, Grace Patlewicz, Andrew RowanRoberta Scherer, Rashid Shaikh, Ted Simon, Douglas Wolf, Joanne Zurlo

Research output: Contribution to journalArticle

Abstract

The Evidence-based Toxicology Collaboration (EBTC) was established recently to translate evidence-based approaches from medicine and health care to toxicology in an organized and sustained effort. The EBTC held a workshop on "Evidence-based Toxicology for the 21st Century: Opportunities and Challenges" in Research Triangle Park, North Carolina, USA on January 24-25, 2012. The presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathwaybased testing methods consistent with the 2007 National Research Council report on "Toxicity Testing in the 21st Century" as well as to adopt a governance structure and work processes to move that effort forward. The workshop served to clarify evidence-based approaches and to provide food for thought on substantive and administrative activities for the EBTC. Priority activities include conducting pilot studies to demonstrate the value of evidence-based approaches to toxicology, as well as conducting educational outreach on these approaches.

Original languageEnglish (US)
Pages (from-to)74-103
Number of pages30
JournalALTEX
Volume30
Issue number1
DOIs
StatePublished - 2013

Keywords

  • Evidence-based medicine
  • Evidence-based toxicology
  • Systematic review
  • Test method assessment
  • Validation

ASJC Scopus subject areas

  • Pharmacology
  • Medical Laboratory Technology

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  • Cite this

    Stephens, M. L., Andersen, M., Becker, R. A., Betts, K., Boekelheide, K., Carney, E., Chapin, R., Devlin, D., Fitzpatrick, S., Fowle, J. R., Harlow, P., Hartung, T., Hoffmann, S., Holsapple, M., Jacobs, A., Judson, R., Naidenko, O., Pastoor, T., Patlewicz, G., ... Zurlo, J. (2013). Evidence-based toxicology for the 21st century: Opportunities and challenges. ALTEX, 30(1), 74-103. https://doi.org/10.14573/altex.2013.1.074