Evidence-based toxicology

Sebastian Hoffmann, Thomas Hartung, Martin L Stephens

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Evidence-based toxicology (EBT) was introduced independently by two groups in 2005, in the context of toxicological risk assessment and causation as well as based on parallels between the evaluation of test methods in toxicology and evidence- based assessment of diagnostics tests in medicine. The role model of evidence- based medicine (EBM) motivated both proposals and guided the evolution of EBT, whereas especially systematic reviews and evidence quality assessment attract considerable attention in toxicology. Regarding test assessment, in the search of solutions for various problems related to validation, such as the imperfectness of the reference standard or the challenge to comprehensively evaluate tests, the fi eld of Diagnostic Test Assessment (DTA) was identifi ed as a potential resource. DTA being an EBM discipline, test method assessment/ validation therefore became one of the main drivers spurring the development of EBT. In the context of pathway-based toxicology, EBT approaches, given their objectivity, transparency and consistency, have been proposed to be used for carrying out a (retrospective) mechanistic validation. In summary, implementation of more evidence-based approaches may provide the tools necessary to adapt the assessment/validation of toxicological test methods and testing strategies to face the challenges of toxicology in the twenty fi rst century.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages231-241
Number of pages11
Volume856
DOIs
StatePublished - Sep 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume856
ISSN (Print)00652598
ISSN (Electronic)22148019

Keywords

  • Diagnostic test assessment
  • Evidence-based toxicology
  • Mechanistic validation
  • Test method assessment
  • Validation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Hoffmann, S., Hartung, T., & Stephens, M. L. (2016). Evidence-based toxicology. In Advances in Experimental Medicine and Biology (Vol. 856, pp. 231-241). (Advances in Experimental Medicine and Biology; Vol. 856). Springer New York LLC. https://doi.org/10.1007/978-3-319-33826-2_9