Evidence-Based Public Health: Moving Beyond Randomized Trials

Cesar G. Victora, Jean Pierre Habicht, Jennifer Bryce

Research output: Contribution to journalReview articlepeer-review

Abstract

Randomized controlled trials (RCTs) are essential for evaluating the efficacy of clinical interventions, where the causal chain between the agent and the outcome is relatively short and simple and where results may be safely extrapolated to other settings. However, causal chains in public health interventions are complex, making RCT results subject to effect modification in different populations. Both the internal and external validity of RCT findings can be greatly enhanced by observational studies using adequacy or plausibility designs. For evaluating large-scale interventions, studies with plausibility designs are often the only feasible option and may provide valid evidence of impact. There is an urgent need to develop evaluation standards and protocols for use in circumstances where RCTs are not appropriate.

Original languageEnglish (US)
Pages (from-to)400-405
Number of pages6
JournalAmerican journal of public health
Volume94
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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