Evidence based medicine in the Intensive Care Unit: Improving care for the septic patient

Robert K. Michaels, Todd Dorman

Research output: Contribution to journalArticlepeer-review


Evidence based medicine (EBM) introduces a systematic approach to caring for patients that integrates scientific evidence with pathophysiologic reasoning, personal experience and patient values. Published reports are accumulating for the treatment of sepsis and septic shock. Using a case-based approach, we sought to review the evidence, specifically the use of early goal-directed therapy, appropriate and timely administration of broad spectrum antibiotics, availability of blood culture results, source control, appropriate assessment for activated protein C, appropriate assessment for and treatment of adrenal insufficiency, and intensive insulin therapy. Incorporation of evidence based interventions, in addition to active research into the pathogenesis and treatment of severe sepsis and septic shock may reduce the unacceptably high mortality of this disease.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalSeminars in Anesthesia, Perioperative Medicine and Pain
Issue number1
StatePublished - Mar 2005


  • Critical care
  • Evidence-based medicine
  • Intensive care
  • Performance improvement
  • Sepsis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Evidence based medicine in the Intensive Care Unit: Improving care for the septic patient'. Together they form a unique fingerprint.

Cite this