Evidence-based feeding strategies before and after the development of necrotizing enterocolitis

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41 Scopus citations


Necrotizing enterocolitis (NEC) is a devastating disease of premature infants and is associated with significant morbidity and mortality. While the pathogenesis of NEC remains incompletely understood, it is well established that the risk of disease is increased by the administration of infant formula and decreased by the administration of breast milk. This review will focus on the mechanisms by which breast milk may serve to protect against NEC, and will review the evidence regarding various feeding strategies that may be utilized before and after an episode of NEC.

Original languageEnglish (US)
Pages (from-to)875-884
Number of pages10
JournalExpert review of clinical immunology
Issue number7
StatePublished - Jul 2014
Externally publishedYes


  • amniotic fluid
  • breast milk
  • growth factors
  • innate immunity
  • necrotizing enterocolitis
  • prematurity
  • toll-like receptor 4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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