TY - JOUR
T1 - Evidence against close linkage of unipolar affective illness to human chromosome 11p markers HRAS1 and INS and chromosome Xq marker DXS52
AU - Neiswanger, Katherine
AU - Slaugenhaupt, Susan A.
AU - Hughes, Hugh B.
AU - Frank, Ellen
AU - Frankel, Debra R.
AU - McCarty, Mary Jane
AU - Chakravarti, Aravinda
AU - Zubenko, George S.
AU - Kupfer, David J.
AU - Kaplan, Barry B.
N1 - Funding Information:
Supported by U.S. Public Health Service Grants MH30915, MH29618, and a grant from the John D. and Cah~erine T. MacArthur Foundation Research Network on the Psychobiology of Depression. Diagnostic interview training and partial pedigree collecf~ion was carried out under a grant from the MacArthur Foundation to Drs. Kenneth Kidd and Myrna Weissman for a multisite study of the Molecular Genetics of Affective Disorders. AC is supported by USPHS Grant GM33771 and is the recipient of NIH Research Career Development Award HD00774. BBK and GSZ are the recipients of ADAMHA Research Scientist Development Awards MH00518 and MH00540, respectively.
PY - 1990/7/1
Y1 - 1990/7/1
N2 - The genetic basis of various subtypes of the affective disorders has been investigated by family, twin, and adoption studies, as well as by segregation and linkage analysis. Linkage analyses of bipolar disorder with the chromosome 11p15 DNA markers HRAS1 and INS, and the chromosome Xq28 markers for color blindness and G6PD have been reported. We have used restriction fragment length polymorphisms as markers to examine linkage in three extended families with unipolar affective illness, ascertained through probands with either recurrent unipolar or bipolar II illness. Using an inclusive definition of the affected phenotype, linkage could be excluded up to 28cM around the HRAS1-INS linkage group on chromosome 11p15, and up to 5cM around the DNA marker DXS52 on Xq28. Negative linkage results were also obtained for two more restrictive definitions of affective illness. Thus, we find no evidence for the involvement of the chromosomal regions 11p15 and Xq28 with unipolar affective disorder in these three families.
AB - The genetic basis of various subtypes of the affective disorders has been investigated by family, twin, and adoption studies, as well as by segregation and linkage analysis. Linkage analyses of bipolar disorder with the chromosome 11p15 DNA markers HRAS1 and INS, and the chromosome Xq28 markers for color blindness and G6PD have been reported. We have used restriction fragment length polymorphisms as markers to examine linkage in three extended families with unipolar affective illness, ascertained through probands with either recurrent unipolar or bipolar II illness. Using an inclusive definition of the affected phenotype, linkage could be excluded up to 28cM around the HRAS1-INS linkage group on chromosome 11p15, and up to 5cM around the DNA marker DXS52 on Xq28. Negative linkage results were also obtained for two more restrictive definitions of affective illness. Thus, we find no evidence for the involvement of the chromosomal regions 11p15 and Xq28 with unipolar affective disorder in these three families.
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U2 - 10.1016/0006-3223(90)90433-3
DO - 10.1016/0006-3223(90)90433-3
M3 - Article
C2 - 1973904
AN - SCOPUS:0025331383
SN - 0006-3223
VL - 28
SP - 63
EP - 72
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 1
ER -