Abstract
Interleukin-10 (IL-10) inhibits intracellular Mycobacterium avium killing by cytokine-activated murine macrophages and may have a role in pathogenesis. Cytokine activities in supernatants of M. avium-infected human monocytes were maximal at 6-24 h for tumor necrosis factor (TNF)-α and 24-48 h for IL-10. TNF-α and IL-10 production increased with increasing M. avium-to-monocyte infection ratios (20:1 to 200:1). TNF-α production by monocytes infected with smooth, domed, and opaque organisms at 200:1 exceeded that of monocytes infected with smooth, flat, and transparent M. avium (P <.01). IL-10 induction demonstrated considerable strain-to-strain variability and did not correlate with intracellular M. avium growth. IL-10 significantly inhibited TNF-α, IL-1β, and IL-6 production by M. avium-infected monocytes. Coculturing monocytes with IL-10 after M. avium infection did not affect intracellular M. avium growth. Differential induction of TNF-α may be a factor in the intracellular growth of M. avium in human monocytes. IL-10, however, played no apparent rule in pathogenicity in this model.
Original language | English (US) |
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Pages (from-to) | 410-417 |
Number of pages | 8 |
Journal | Journal of Infectious Diseases |
Volume | 173 |
Issue number | 2 |
State | Published - 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology