Evaluation of WHO criteria for viral failure in patients on antiretroviral treatment in resource-limited settings

Barbara Castelnuovo, Joseph Sempa, Kiragga N. Agnes, Moses R. Kamya, Yukari C. Manabe

Research output: Contribution to journalArticlepeer-review

Abstract

Our objective was to evaluate outcomes in patients with sustained viral suppression compared to those with episodes of viremia. Methods. In a prospective cohort of patients started on ART in Uganda and followed for 48 months, patients were categorized according to viral load (VL): (1) sustained-suppression: (VL ≤1,000 copies/mL) (2) VL 1,001-10,000, or (3) VL >10,000. Results. Fifty-Three (11.2%) and 84 (17.8%) patients had a first episode of intermediate and high viremia, respectively. Patients with sustained suppression had better CD4+ T cell count increases over time compared to viremic patients (P <.001). The majority of patients with viremia achieved viral suppression when the measurement was repeated. Only 39.6% of patients with intermediate and 19.1% with high viremia eventually needed to be switched to second line (P =.008). Conclusions. The use of at least one repeat measurement rather than a single VL measurement could avert from 60% to 80% of unnecessary switches.

Original languageEnglish (US)
Article number736938
JournalAIDS Research and Treatment
Volume2011
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Evaluation of WHO criteria for viral failure in patients on antiretroviral treatment in resource-limited settings'. Together they form a unique fingerprint.

Cite this