Evaluation of use of a single intravaginal swab to detect multiple sexually transmitted infections in active-duty military women

Anne Marie Rompalo, Charlotte A Gaydos, Nina Shah, Marie Tennant, Kimberly A. Crotchfelt, Guillermo Madico, Thomas C Quinn, Richard Daniel, Keerti V. Shah, Joel C. Gaydos, Kelly T. McKee

Research output: Contribution to journalArticle

Abstract

The accuracy and suitability of use of a single intravaginal swab (SIS) for polymerase chain reaction detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, and human papillomavirus infection was assessed in a cross-sectional study of 841 active-duty military women. The SIS, compared with standard diagnostic tests, allowed detection of more gonorrhea, more chlamydial infection, and more trichomoniasis. Sensitivity and specificity of SIS detection compared with adjudicated true-positive diagnoses were 95.8% and 97.8%, respectively, for gonorrhea, 94.6% and 99.3% for chlamydial infection, and 92.2% and 98.2% for trichomonal infection. Results with SISs were comparable to those with cervical swabs tested for human papillomavirus. Assay of clinician-collected and self-collected SISs yielded prevalences similar to those of standard diagnostic tests for all sexually transmitted infections. Therefore, the use of SISs is acceptable for the simultaneous diagnosis of multiple sexually transmitted infections and has potential for use as a self-administered diagnostic tool with widespread applicability among women.

Original languageEnglish (US)
Pages (from-to)1455-1461
Number of pages7
JournalClinical Infectious Diseases
Volume33
Issue number9
DOIs
StatePublished - Nov 1 2001

Fingerprint

Sexually Transmitted Diseases
Gonorrhea
Routine Diagnostic Tests
Infection
Trichomonas vaginalis
Papillomavirus Infections
Neisseria gonorrhoeae
Chlamydia trachomatis
Cross-Sectional Studies
Sensitivity and Specificity
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Immunology

Cite this

Evaluation of use of a single intravaginal swab to detect multiple sexually transmitted infections in active-duty military women. / Rompalo, Anne Marie; Gaydos, Charlotte A; Shah, Nina; Tennant, Marie; Crotchfelt, Kimberly A.; Madico, Guillermo; Quinn, Thomas C; Daniel, Richard; Shah, Keerti V.; Gaydos, Joel C.; McKee, Kelly T.

In: Clinical Infectious Diseases, Vol. 33, No. 9, 01.11.2001, p. 1455-1461.

Research output: Contribution to journalArticle

Rompalo, Anne Marie ; Gaydos, Charlotte A ; Shah, Nina ; Tennant, Marie ; Crotchfelt, Kimberly A. ; Madico, Guillermo ; Quinn, Thomas C ; Daniel, Richard ; Shah, Keerti V. ; Gaydos, Joel C. ; McKee, Kelly T. / Evaluation of use of a single intravaginal swab to detect multiple sexually transmitted infections in active-duty military women. In: Clinical Infectious Diseases. 2001 ; Vol. 33, No. 9. pp. 1455-1461.
@article{294d92486d2e4b0f8b619e6e72ac66ac,
title = "Evaluation of use of a single intravaginal swab to detect multiple sexually transmitted infections in active-duty military women",
abstract = "The accuracy and suitability of use of a single intravaginal swab (SIS) for polymerase chain reaction detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, and human papillomavirus infection was assessed in a cross-sectional study of 841 active-duty military women. The SIS, compared with standard diagnostic tests, allowed detection of more gonorrhea, more chlamydial infection, and more trichomoniasis. Sensitivity and specificity of SIS detection compared with adjudicated true-positive diagnoses were 95.8{\%} and 97.8{\%}, respectively, for gonorrhea, 94.6{\%} and 99.3{\%} for chlamydial infection, and 92.2{\%} and 98.2{\%} for trichomonal infection. Results with SISs were comparable to those with cervical swabs tested for human papillomavirus. Assay of clinician-collected and self-collected SISs yielded prevalences similar to those of standard diagnostic tests for all sexually transmitted infections. Therefore, the use of SISs is acceptable for the simultaneous diagnosis of multiple sexually transmitted infections and has potential for use as a self-administered diagnostic tool with widespread applicability among women.",
author = "Rompalo, {Anne Marie} and Gaydos, {Charlotte A} and Nina Shah and Marie Tennant and Crotchfelt, {Kimberly A.} and Guillermo Madico and Quinn, {Thomas C} and Richard Daniel and Shah, {Keerti V.} and Gaydos, {Joel C.} and McKee, {Kelly T.}",
year = "2001",
month = "11",
day = "1",
doi = "10.1086/322588",
language = "English (US)",
volume = "33",
pages = "1455--1461",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Evaluation of use of a single intravaginal swab to detect multiple sexually transmitted infections in active-duty military women

AU - Rompalo, Anne Marie

AU - Gaydos, Charlotte A

AU - Shah, Nina

AU - Tennant, Marie

AU - Crotchfelt, Kimberly A.

AU - Madico, Guillermo

AU - Quinn, Thomas C

AU - Daniel, Richard

AU - Shah, Keerti V.

AU - Gaydos, Joel C.

AU - McKee, Kelly T.

PY - 2001/11/1

Y1 - 2001/11/1

N2 - The accuracy and suitability of use of a single intravaginal swab (SIS) for polymerase chain reaction detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, and human papillomavirus infection was assessed in a cross-sectional study of 841 active-duty military women. The SIS, compared with standard diagnostic tests, allowed detection of more gonorrhea, more chlamydial infection, and more trichomoniasis. Sensitivity and specificity of SIS detection compared with adjudicated true-positive diagnoses were 95.8% and 97.8%, respectively, for gonorrhea, 94.6% and 99.3% for chlamydial infection, and 92.2% and 98.2% for trichomonal infection. Results with SISs were comparable to those with cervical swabs tested for human papillomavirus. Assay of clinician-collected and self-collected SISs yielded prevalences similar to those of standard diagnostic tests for all sexually transmitted infections. Therefore, the use of SISs is acceptable for the simultaneous diagnosis of multiple sexually transmitted infections and has potential for use as a self-administered diagnostic tool with widespread applicability among women.

AB - The accuracy and suitability of use of a single intravaginal swab (SIS) for polymerase chain reaction detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, and human papillomavirus infection was assessed in a cross-sectional study of 841 active-duty military women. The SIS, compared with standard diagnostic tests, allowed detection of more gonorrhea, more chlamydial infection, and more trichomoniasis. Sensitivity and specificity of SIS detection compared with adjudicated true-positive diagnoses were 95.8% and 97.8%, respectively, for gonorrhea, 94.6% and 99.3% for chlamydial infection, and 92.2% and 98.2% for trichomonal infection. Results with SISs were comparable to those with cervical swabs tested for human papillomavirus. Assay of clinician-collected and self-collected SISs yielded prevalences similar to those of standard diagnostic tests for all sexually transmitted infections. Therefore, the use of SISs is acceptable for the simultaneous diagnosis of multiple sexually transmitted infections and has potential for use as a self-administered diagnostic tool with widespread applicability among women.

UR - http://www.scopus.com/inward/record.url?scp=0035502920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035502920&partnerID=8YFLogxK

U2 - 10.1086/322588

DO - 10.1086/322588

M3 - Article

C2 - 11568849

AN - SCOPUS:0035502920

VL - 33

SP - 1455

EP - 1461

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 9

ER -