Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya

Lee M. Hampton, Godfrey Bigogo, Geofrey Jagero, Maria da Gloria Carvalho, Fabiana Pimenta, Muthoni Junghae, Robert F. Breiman, Cynthia G. Whitney, Daniel Feikin, Laura M. Conklin

Research output: Contribution to journalArticle

Abstract

When used in an area of rural western Kenya, the BinaxNOW® urine antigen test had a sensitivity of 67% (95% Confidence Interval [CI]: 43–85%) among 21 adults ≥15 years old with acute respiratory illnesses and pneumococcal bacteremia and a specificity of 98% (95% CI: 96–99%) among 660 adults ≥15 years old without fever or cough. The specificity of the test was not significantly affected by pneumococcal colonization, regardless of patients’ HIV status, age, or sex. Use of the pneumococcal urine antigen test in clinical assessments of adults in Africa with acute respiratory illness is a viable option regardless of whether a patient is colonized by pneumococci, even among HIV-infected adults, although the moderate sensitivity of the urine antigen test indicates that the test is probably best used clinically as part of a panel with other tests that can detect pneumococci.

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume85
Issue number4
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Fingerprint

Kenya
Urine
Streptococcus pneumoniae
Antigens
HIV
Confidence Intervals
Bacteremia
Cough
Fever

Keywords

  • Africa
  • HIV
  • Kenya
  • Nasopharyngeal colonization
  • Pneumococcus
  • Streptococcus pneumoniae
  • Urine pneumococcal antigen test

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Hampton, L. M., Bigogo, G., Jagero, G., da Gloria Carvalho, M., Pimenta, F., Junghae, M., ... Conklin, L. M. (2016). Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya. Diagnostic Microbiology and Infectious Disease, 85(4), 405-408. https://doi.org/10.1016/j.diagmicrobio.2016.04.027

Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya. / Hampton, Lee M.; Bigogo, Godfrey; Jagero, Geofrey; da Gloria Carvalho, Maria; Pimenta, Fabiana; Junghae, Muthoni; Breiman, Robert F.; Whitney, Cynthia G.; Feikin, Daniel; Conklin, Laura M.

In: Diagnostic Microbiology and Infectious Disease, Vol. 85, No. 4, 01.08.2016, p. 405-408.

Research output: Contribution to journalArticle

Hampton, LM, Bigogo, G, Jagero, G, da Gloria Carvalho, M, Pimenta, F, Junghae, M, Breiman, RF, Whitney, CG, Feikin, D & Conklin, LM 2016, 'Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya', Diagnostic Microbiology and Infectious Disease, vol. 85, no. 4, pp. 405-408. https://doi.org/10.1016/j.diagmicrobio.2016.04.027
Hampton, Lee M. ; Bigogo, Godfrey ; Jagero, Geofrey ; da Gloria Carvalho, Maria ; Pimenta, Fabiana ; Junghae, Muthoni ; Breiman, Robert F. ; Whitney, Cynthia G. ; Feikin, Daniel ; Conklin, Laura M. / Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya. In: Diagnostic Microbiology and Infectious Disease. 2016 ; Vol. 85, No. 4. pp. 405-408.
@article{1baef120777d49cbb3483ce7b434335b,
title = "Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya",
abstract = "When used in an area of rural western Kenya, the BinaxNOW{\^A}{\circledR} urine antigen test had a sensitivity of 67{\%} (95{\%} Confidence Interval [CI]: 43–85{\%}) among 21 adults ≥15 years old with acute respiratory illnesses and pneumococcal bacteremia and a specificity of 98{\%} (95{\%} CI: 96–99{\%}) among 660 adults ≥15 years old without fever or cough. The specificity of the test was not significantly affected by pneumococcal colonization, regardless of patients’ HIV status, age, or sex. Use of the pneumococcal urine antigen test in clinical assessments of adults in Africa with acute respiratory illness is a viable option regardless of whether a patient is colonized by pneumococci, even among HIV-infected adults, although the moderate sensitivity of the urine antigen test indicates that the test is probably best used clinically as part of a panel with other tests that can detect pneumococci.",
keywords = "Africa, HIV, Kenya, Nasopharyngeal colonization, Pneumococcus, Streptococcus pneumoniae, Urine pneumococcal antigen test",
author = "Hampton, {Lee M.} and Godfrey Bigogo and Geofrey Jagero and {da Gloria Carvalho}, Maria and Fabiana Pimenta and Muthoni Junghae and Breiman, {Robert F.} and Whitney, {Cynthia G.} and Daniel Feikin and Conklin, {Laura M.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1016/j.diagmicrobio.2016.04.027",
language = "English (US)",
volume = "85",
pages = "405--408",
journal = "Diagnostic Microbiology and Infectious Disease",
issn = "0732-8893",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya

AU - Hampton, Lee M.

AU - Bigogo, Godfrey

AU - Jagero, Geofrey

AU - da Gloria Carvalho, Maria

AU - Pimenta, Fabiana

AU - Junghae, Muthoni

AU - Breiman, Robert F.

AU - Whitney, Cynthia G.

AU - Feikin, Daniel

AU - Conklin, Laura M.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - When used in an area of rural western Kenya, the BinaxNOW® urine antigen test had a sensitivity of 67% (95% Confidence Interval [CI]: 43–85%) among 21 adults ≥15 years old with acute respiratory illnesses and pneumococcal bacteremia and a specificity of 98% (95% CI: 96–99%) among 660 adults ≥15 years old without fever or cough. The specificity of the test was not significantly affected by pneumococcal colonization, regardless of patients’ HIV status, age, or sex. Use of the pneumococcal urine antigen test in clinical assessments of adults in Africa with acute respiratory illness is a viable option regardless of whether a patient is colonized by pneumococci, even among HIV-infected adults, although the moderate sensitivity of the urine antigen test indicates that the test is probably best used clinically as part of a panel with other tests that can detect pneumococci.

AB - When used in an area of rural western Kenya, the BinaxNOW® urine antigen test had a sensitivity of 67% (95% Confidence Interval [CI]: 43–85%) among 21 adults ≥15 years old with acute respiratory illnesses and pneumococcal bacteremia and a specificity of 98% (95% CI: 96–99%) among 660 adults ≥15 years old without fever or cough. The specificity of the test was not significantly affected by pneumococcal colonization, regardless of patients’ HIV status, age, or sex. Use of the pneumococcal urine antigen test in clinical assessments of adults in Africa with acute respiratory illness is a viable option regardless of whether a patient is colonized by pneumococci, even among HIV-infected adults, although the moderate sensitivity of the urine antigen test indicates that the test is probably best used clinically as part of a panel with other tests that can detect pneumococci.

KW - Africa

KW - HIV

KW - Kenya

KW - Nasopharyngeal colonization

KW - Pneumococcus

KW - Streptococcus pneumoniae

KW - Urine pneumococcal antigen test

UR - http://www.scopus.com/inward/record.url?scp=84975529215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975529215&partnerID=8YFLogxK

U2 - 10.1016/j.diagmicrobio.2016.04.027

DO - 10.1016/j.diagmicrobio.2016.04.027

M3 - Article

C2 - 27220607

AN - SCOPUS:84975529215

VL - 85

SP - 405

EP - 408

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

SN - 0732-8893

IS - 4

ER -