Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya

Lee M. Hampton, Godfrey Bigogo, Geofrey Jagero, Maria da Gloria Carvalho, Fabiana Pimenta, Muthoni Junghae, Robert F. Breiman, Cynthia G. Whitney, Daniel R. Feikin, Laura M. Conklin

Research output: Contribution to journalArticlepeer-review

Abstract

When used in an area of rural western Kenya, the BinaxNOW® urine antigen test had a sensitivity of 67% (95% Confidence Interval [CI]: 43–85%) among 21 adults ≥15 years old with acute respiratory illnesses and pneumococcal bacteremia and a specificity of 98% (95% CI: 96–99%) among 660 adults ≥15 years old without fever or cough. The specificity of the test was not significantly affected by pneumococcal colonization, regardless of patients’ HIV status, age, or sex. Use of the pneumococcal urine antigen test in clinical assessments of adults in Africa with acute respiratory illness is a viable option regardless of whether a patient is colonized by pneumococci, even among HIV-infected adults, although the moderate sensitivity of the urine antigen test indicates that the test is probably best used clinically as part of a panel with other tests that can detect pneumococci.

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume85
Issue number4
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Keywords

  • Africa
  • HIV
  • Kenya
  • Nasopharyngeal colonization
  • Pneumococcus
  • Streptococcus pneumoniae
  • Urine pneumococcal antigen test

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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