Abstract
In this report we describe studies with N5-2OH, a carboranyl thymidine analog (CTA), which is a substrate for thymidine kinase 1 (TK1), using the F98 rat glioma model. In vivo BNCT studies have demonstrated that intracerebral (i.c.) osmotic pump infusion of N5-2OH yielded survival data equivalent to those obtained with i.v. administration of boronophenylalanine (BPA). The combination of N5-2OH and BPA resulted in a modest increase in MST of F98 glioma bearing rats compared to a statistically significant increase with the RG2 glioma model, as has been previously reported by us (. Barth et al., 2008). This had lead us to synthesize a second generation of CTAs that have improved in vitro enzyme kinetics and in vivo tumor uptake ( Agarwal et al., 2015).
Original language | English (US) |
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Pages (from-to) | 251-255 |
Number of pages | 5 |
Journal | Applied Radiation and Isotopes |
Volume | 106 |
DOIs | |
State | Published - Dec 1 2015 |
Externally published | Yes |
Keywords
- BNCT
- Carboranyl thymidine analogs
- F98 rat glioma
- N5-2OH
ASJC Scopus subject areas
- Radiation