Evaluation of the stable coronary artery disease patient: Anatomy trumps physiology

Karan Desai, Mandeep S. Sidhu, William E. Boden

Research output: Contribution to journalReview article

Abstract

The past decade has been associated with profound progress in both the assessment and treatment of stable ischemic heart disease (SIHD) patients. The many randomized clinical trials, observational studies, and post hoc analyses continue to elucidate the role of coronary anatomy and ischemic burden in treating our patients in routine clinical practice, with the preponderance of the current scientific evidence base suggesting that coronary anatomy does indeed trump physiology in predicting future coronary events in SIHD patients. However, the many clinical studies and post hoc analyses, while provocative, are relatively underpowered; therefore, an important question remains as to whether anatomic burden or ischemic burden can most reliably identify patients who would derive clinical benefits from an initial invasive strategy, regardless of prognostic value.

Original languageEnglish (US)
Pages (from-to)332-340
Number of pages9
JournalTrends in Cardiovascular Medicine
Volume24
Issue number8
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Coronary Artery Disease
Anatomy
Myocardial Ischemia
Observational Studies
Randomized Controlled Trials
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Evaluation of the stable coronary artery disease patient : Anatomy trumps physiology. / Desai, Karan; Sidhu, Mandeep S.; Boden, William E.

In: Trends in Cardiovascular Medicine, Vol. 24, No. 8, 01.01.2014, p. 332-340.

Research output: Contribution to journalReview article

Desai, Karan ; Sidhu, Mandeep S. ; Boden, William E. / Evaluation of the stable coronary artery disease patient : Anatomy trumps physiology. In: Trends in Cardiovascular Medicine. 2014 ; Vol. 24, No. 8. pp. 332-340.
@article{8518ce23eb8342bf8cfc1949532db6d8,
title = "Evaluation of the stable coronary artery disease patient: Anatomy trumps physiology",
abstract = "The past decade has been associated with profound progress in both the assessment and treatment of stable ischemic heart disease (SIHD) patients. The many randomized clinical trials, observational studies, and post hoc analyses continue to elucidate the role of coronary anatomy and ischemic burden in treating our patients in routine clinical practice, with the preponderance of the current scientific evidence base suggesting that coronary anatomy does indeed trump physiology in predicting future coronary events in SIHD patients. However, the many clinical studies and post hoc analyses, while provocative, are relatively underpowered; therefore, an important question remains as to whether anatomic burden or ischemic burden can most reliably identify patients who would derive clinical benefits from an initial invasive strategy, regardless of prognostic value.",
author = "Karan Desai and Sidhu, {Mandeep S.} and Boden, {William E.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.tcm.2014.08.003",
language = "English (US)",
volume = "24",
pages = "332--340",
journal = "Trends in Cardiovascular Medicine",
issn = "1050-1738",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Evaluation of the stable coronary artery disease patient

T2 - Anatomy trumps physiology

AU - Desai, Karan

AU - Sidhu, Mandeep S.

AU - Boden, William E.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The past decade has been associated with profound progress in both the assessment and treatment of stable ischemic heart disease (SIHD) patients. The many randomized clinical trials, observational studies, and post hoc analyses continue to elucidate the role of coronary anatomy and ischemic burden in treating our patients in routine clinical practice, with the preponderance of the current scientific evidence base suggesting that coronary anatomy does indeed trump physiology in predicting future coronary events in SIHD patients. However, the many clinical studies and post hoc analyses, while provocative, are relatively underpowered; therefore, an important question remains as to whether anatomic burden or ischemic burden can most reliably identify patients who would derive clinical benefits from an initial invasive strategy, regardless of prognostic value.

AB - The past decade has been associated with profound progress in both the assessment and treatment of stable ischemic heart disease (SIHD) patients. The many randomized clinical trials, observational studies, and post hoc analyses continue to elucidate the role of coronary anatomy and ischemic burden in treating our patients in routine clinical practice, with the preponderance of the current scientific evidence base suggesting that coronary anatomy does indeed trump physiology in predicting future coronary events in SIHD patients. However, the many clinical studies and post hoc analyses, while provocative, are relatively underpowered; therefore, an important question remains as to whether anatomic burden or ischemic burden can most reliably identify patients who would derive clinical benefits from an initial invasive strategy, regardless of prognostic value.

UR - http://www.scopus.com/inward/record.url?scp=84923139060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923139060&partnerID=8YFLogxK

U2 - 10.1016/j.tcm.2014.08.003

DO - 10.1016/j.tcm.2014.08.003

M3 - Review article

C2 - 25241252

AN - SCOPUS:84923139060

VL - 24

SP - 332

EP - 340

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

SN - 1050-1738

IS - 8

ER -